Complement mediates binding and procoagulant effects of ultra-large HIT immune complexes.
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DOI: 10.1182/blood.2020009487
Abstract: Heparin-induced thrombocytopenia (HIT) is a prothrombotic disorder mediated by ultra-large immune complexes (ULICs) containing IgG antibodies to a multivalent antigen composed of platelet factor 4 (PF4) and heparin. The limitations of current anti-thrombotic therapy in… read more here.
Keywords: immune; immune complexes; complement mediates; ultra large ... See more keywords