The role of complement membrane attack complex in dry and wet AMD - From hypothesis to clinical trials.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental eye research"
DOI: 10.1016/j.exer.2019.05.006
Abstract: Data from human dry and wet age-related macular degeneration (AMD) eyes support the hypothesis that constant 'tickover' of the alternative complement pathway results in chronic deposition of the complement membrane attack complex (MAC) on the… read more here.
Keywords: complement membrane; dry wet; wet amd; membrane attack ... See more keywords
CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07653-5
Abstract: The membrane attack complex (MAC) is one of the immune system’s first responders. Complement proteins assemble on target membranes to form pores that lyse pathogens and impact tissue homeostasis of self-cells. How MAC disrupts the… read more here.
Keywords: attack complex; complement membrane; lipid bilayers; membrane attack ... See more keywords
Complement Membrane Attack Complexes Assemble NLRP3 Inflammasomes Triggering IL-1 Activation of IFN-γ-Primed Human Endothelium.
Sign Up to like & getrecommendations! Published in 2019 at "Circulation research"
DOI: 10.1161/circresaha.119.314845
Abstract: RATIONALE Complement activation contributes to multiple immune-mediated pathologies. In late allograft failure, donor-specific antibody deposits complement membrane attack complexes (MAC) on graft endothelial cells (ECs), substantially increasing their immunogenicity without causing lysis. Internalized MAC stabilize… read more here.
Keywords: activation; complement membrane; membrane attack; mac ... See more keywords