A Randomized, First‐in‐Human, Healthy Volunteer Trial of sutimlimab, a Humanized Antibody for the Specific Inhibition of the Classical Complement Pathway
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.1111
Abstract: Aberrant activation of the classical complement pathway is the common underlying pathophysiology of orphan diseases such as bullous pemphigoid, antibody‐mediated rejection of organ transplants, cold agglutinin disease, and warm autoimmune hemolytic anemia. Therapeutic options for… read more here.
Keywords: inhibition classical; sutimlimab humanized; complement pathway; classical complement ... See more keywords
COVID-19 microthrombosis: unusually large VWF multimers are a platform for activation of the alternative complement pathway under cytokine storm
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Hematology"
DOI: 10.1007/s12185-022-03324-w
Abstract: ADAMTS13, a metalloproteinase, specifically cleaves unusually large multimers of von Willebrand factor (VWF), newly released from vascular endothelial cells. The ratio of ADAMTS13 activity to VWF antigen (ADAMTS13/VWF) and indicators of the alternative complement pathway… read more here.
Keywords: unusually large; activation; alternative complement; vwf ... See more keywords
Alternative complement pathway hemolytic assays reveal incomplete complement blockade in patients treated with eculizumab.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical immunology"
DOI: 10.1016/j.clim.2017.06.007
Abstract: Eculizumab is a monoclonal anti-C5 antibody used in the treatment of atypical hemolytic uremic syndrome (aHUS). We monitored complement inhibition in 16 eculizumab-treated patients suffering from HUS or transplant rejection (not aHUS patients). Blood samples… read more here.
Keywords: alternative complement; complement pathway; pathway hemolytic; blockade ... See more keywords
Recombinant C1q variants modulate macrophage responses but do not activate the classical complement pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular immunology"
DOI: 10.1016/j.molimm.2019.10.008
Abstract: Complement protein C1q plays a dual role in a number of inflammatory diseases such as atherosclerosis. While in later stages classical complement pathway activation by C1q exacerbates disease progression, C1q also plays a beneficial role… read more here.
Keywords: rc1q; complement pathway; classical complement; c1q ... See more keywords
The complement cascade in Alzheimer’s disease: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Psychiatry"
DOI: 10.1038/s41380-019-0536-8
Abstract: Genetic evidence implicates a causal role for the complement pathway in Alzheimer’s disease (AD). Since studies have shown inconsistent differences in cerebrospinal fluid (CSF) and peripheral blood complement protein concentrations between AD patients and healthy… read more here.
Keywords: protein; alzheimer disease; complement pathway; complement ... See more keywords
Human anti-thrombospondin type 1 domain-containing 7A antibodies induce membranous nephropathy through activation of lectin complement pathway
Sign Up to like & getrecommendations! Published in 2018 at "Bioscience Reports"
DOI: 10.1042/bsr20180131
Abstract: To investigate whether the human anti-thrombospondin type 1 domain-containing 7A (THSD7A) antibody-induced membranous nephropathy (MN) is mediated by activating lectin complement pathway. Automatic biochemical apparatus was used to assess renal function of mice. The serum… read more here.
Keywords: complement pathway; lectin complement; thsd7a; human anti ... See more keywords
Genetic analysis of the complement pathway in C3 glomerulopathy
Sign Up to like & getrecommendations! Published in 2018 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfy033
Abstract: Background C3 glomerulopathy often presents with a membranoproliferative glomerulonephritis (MPGN) pattern, and is principally caused by unrestricted activation of the complement alternative pathway. Genetic abnormalities of the complement system critically implicate in the pathogenesis of… read more here.
Keywords: analysis complement; complement pathway; alternative pathway; complement ... See more keywords
O1.1 ALTERED COMPLEMENT PATHWAY PROTEIN EXPRESSION IS ASSOCIATED WITH PSYCHOTIC EXPERIENCES AT AGE 11 WHICH PERSIST AT AGE 18
Sign Up to like & getrecommendations! Published in 2018 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sby015.183
Abstract: Abstract Background The identification of early biomarkers of psychotic disorder is important because early treatment is associated with improved outcome. We have previously shown that altered complement and coagulation pathway associated proteins are associated pathway… read more here.
Keywords: age; complement pathway; psychotic experiences; experiences age ... See more keywords
Alternative Complement Pathway Activation Provokes A Hypercoagulable State with Diminished Fibrinolysis.
Sign Up to like & getrecommendations! Published in 2019 at "Shock"
DOI: 10.1097/shk.0000000000001437
Abstract: INTRODUCTION Several disease processes trigger prolonged activation of the alternative complement pathway. Crosslinks between complement activation and physiologic changes in platelets and neutrophils have been identified, but how this interplay alters the hemostatic potential in… read more here.
Keywords: activation; fibrinolysis; complement pathway; alternative complement ... See more keywords
Tissue microarray methodology identifies complement pathway activation and dysregulation in progressive multiple sclerosis
Sign Up to like & getrecommendations! Published in 2018 at "Brain Pathology"
DOI: 10.1111/bpa.12546
Abstract: The complement pathway has potential contributions to both white (WM) and grey matter (GM) pathology in Multiple Sclerosis (MS). A quantitative assessment of complement involvement is lacking. Here we describe the use of Tissue MicroArray… read more here.
Keywords: methodology; complement pathway; tissue; pathology ... See more keywords
First‐in‐human study with SAR445088: A novel selective classical complement pathway inhibitor
Sign Up to like & getrecommendations! Published in 2023 at "Clinical and Translational Science"
DOI: 10.1111/cts.13481
Abstract: SAR445088 is an anti‐C1s humanized monoclonal antibody that inhibits activated C1s in the proximal portion of the classical complement system and has the potential to provide clinical benefit in the treatment of complement‐mediated diseases. A… read more here.
Keywords: complement; complement pathway; complement mediated; classical complement ... See more keywords