Age‐specific pediatric reference ranges for immunoglobulins and complement proteins on the Optilite™ automated turbidimetric analyzer
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.22420
Abstract: Measurement of immunoglobulins and complement proteins are frontline tests used in the assessment of immune system integrity, and reference values can vary with age. Their measurement provides an insight into the function of the innate… read more here.
Keywords: specific pediatric; immunoglobulins complement; reference; complement proteins ... See more keywords
The covalent binding story of the complement proteins C3 and C4 (I) 1972-1981.
Sign Up to like & getrecommendations! Published in 2019 at "Immunobiology"
DOI: 10.1016/j.imbio.2019.08.003
Abstract: Alex Law and Paul Levine recall their work to establish the covalent bond between C3 and target surfaces. It started with a naive experiment by analyzing the membrane polypeptides of sheep erythrocytes bound with 125I-labelled… read more here.
Keywords: covalent binding; proteins 1972; 1972 1981; binding story ... See more keywords
High levels of urinary complement proteins are associated with chronic renal damage and proximal tubule dysfunction in immunoglobulin A nephropathy
Sign Up to like & getrecommendations! Published in 2019 at "Nephrology"
DOI: 10.1111/nep.13477
Abstract: Complement activation is involved in the pathogenesis and progression of immunoglobulin A nephropathy (IgAN); however, the clinical implication of abnormal complement protein levels in serum and urine is not clear. To address this we analyzed… read more here.
Keywords: immunoglobulin nephropathy; high levels; complement; complement proteins ... See more keywords
Abstract MP36: Changes in High-density Lipoprotein (hdl) Subclasses and Particle Size Over the Menopause Transition are Associated With Higher Levels of Complement Proteins C3 and C4. The Study of Women's Health Across the Nation Hdl Ancillary Study
Sign Up to like & getrecommendations! Published in 2020 at "Circulation"
DOI: 10.1161/circ.141.suppl_1.mp36
Abstract: Objective: High density lipoprotein (HDL) is emerging as a key player in modulating inflammation-related response impacting atherosclerosis development. HDL carries multiple proteins with direct roles in complement system activation including C3 and C4. Postmenopausal women… read more here.
Keywords: particle size; higher levels; hdl; size ... See more keywords
Complement proteins in unexpected places: why we should be excited, not concerned!
Sign Up to like & getrecommendations! Published in 2020 at "F1000Research"
DOI: 10.12688/f1000research.21690.1
Abstract: The complement system consists of more than 30 plasma as well as cell surface proteins that together constitute a major arm of the immune system. The long-held belief is that most of the complement components… read more here.
Keywords: unexpected places; proteins unexpected; excited concerned; complement ... See more keywords
Different Complement Activation Pathways Underly Cognitive Impairment and Type 2 Diabetes Mellitus Combined With Cognitive Impairment
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.810335
Abstract: Background The immune response and the complement system are associated with cognitive impairment and diabetes mellitus, respectively. Activation of the complement system in these diseases occurs mainly through either the classical pathway or the alternative… read more here.
Keywords: t2dm cognitive; impairment; cognitive impairment; diabetes mellitus ... See more keywords
Significance of urine complement proteins in monitoring lupus activity
Sign Up to like & getrecommendations! Published in 2022 at "PeerJ"
DOI: 10.7717/peerj.14383
Abstract: Objectives Complement activation is a critical feature in the development of systemic lupus erythematosus (SLE). Whether there are changes of complement components in the urine of SLE has not been reported. The aim of the… read more here.
Keywords: complement; disease activity; activity; complement proteins ... See more keywords
Urinary complement proteins in IgA nephropathy progression from a relative quantitative proteomic analysis
Sign Up to like & getrecommendations! Published in 2023 at "PeerJ"
DOI: 10.7717/peerj.15125
Abstract: Aim IgA nephropathy (IgAN) is one of the leading causes of end-stage renal disease (ESRD). Urine testing is a non-invasive way to track the biomarkers used for measuring renal injury. This study aimed to analyse… read more here.
Keywords: urinary complement; iga nephropathy; complement; progression ... See more keywords