Genetic variability shapes the alternative pathway complement activity and predisposition to complement‐related diseases
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DOI: 10.1111/imr.13131
Abstract: The implementation of next‐generation sequencing technologies has provided a sharp picture of the genetic variability in the components and regulators of the alternative pathway (AP) of the complement system and has revealed the association of… read more here.
Keywords: genetic variability; pathway complement; alternative pathway; complement ... See more keywords
Identification of Complement-Related Missense Variants in Pediatric Patients with Acute and Post COVID-19 Syndromes
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DOI: 10.1182/blood-2021-149382
Abstract: Background: Complement dysregulation has been documented in the molecular pathophysiology of COVID-19 and recently implicated in the relevant pediatric patient inflammatory responses. Aims: Based on our previous data in adults, we hypothesized that signatures of… read more here.
Keywords: analysis; covid; clinical trials; pediatric patients ... See more keywords
Construction and validation of a prognostic model for predicting clear cell renal cell carcinoma based on complement-related genes
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DOI: 10.21037/tau-23-187
Abstract: Background Clear cell renal cell carcinoma (ccRCC) is a highly heterogeneous tumor and is the most common subtype of renal cell carcinoma (RCC). Surgery is used to cure most early ccRCC, but the 5-year overall… read more here.
Keywords: cell; analysis; model; related genes ... See more keywords