Manipulating the complement system via Therapeutic plasmapheresis: Is there any therapeutic role?
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Apheresis"
DOI: 10.1002/jca.22001
Abstract: The complement system was discovered over a 100 years ago and now seems more sophisticated than originally thought. Complements have a role beyond innate immunity. Early complement components intervene on the rapid uptake of debris… read more here.
Keywords: system; role; complement system; plasma ... See more keywords
Analysis of Complement Activation by Nanoparticles.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7352-1_13
Abstract: The complement system is a group of proteins, which function in plasma to assist the innate immunity in rapid clearance of pathogens. The complement system also contributes to coordination of the adaptive immune response. Complement… read more here.
Keywords: analysis complement; complement system; complement; complement activation ... See more keywords
Activation status of peripheral blood neutrophils and the complement system in adult rheumatoid arthritis patients undergoing combined therapy with infliximab and methotrexate
Sign Up to like & getrecommendations! Published in 2018 at "Rheumatology International"
DOI: 10.1007/s00296-018-3997-1
Abstract: We examined the functional activity of peripheral blood neutrophils and the complement system activation status in patients with rheumatoid arthritis (RA) undergoing infliximab/methotrexate combined therapy. We studied female RA patients under treatment with infliximab (3–5 mg/kg)… read more here.
Keywords: complement; infliximab methotrexate; complement system; activation ... See more keywords
European Society for Immunodeficiencies (ESID) and European Reference Network on Rare Primary Immunodeficiency, Autoinflammatory and Autoimmune Diseases (ERN RITA) Complement Guideline: Deficiencies, Diagnosis, and Management
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Immunology"
DOI: 10.1007/s10875-020-00754-1
Abstract: This guideline aims to describe the complement system and the functions of the constituent pathways, with particular focus on primary immunodeficiencies (PIDs) and their diagnosis and management. The complement system is a crucial part of the… read more here.
Keywords: system; diagnosis management; autoimmune diseases; complement system ... See more keywords
Coagulopathy, endothelial dysfunction, thrombotic microangiopathy and complement activation: potential role of complement system inhibition in COVID-19
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-020-02297-z
Abstract: Coronavirus disease-2019 (COVID-19) is a rapidly evolving health crisis caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is a novel disease entity and we are in a learning phase with regards to… read more here.
Keywords: covid; complement; complement activation; complement system ... See more keywords
Evasion of the complement system by Leishmania through the uptake of factor H, a complement regulatory protein.
Sign Up to like & getrecommendations! Published in 2021 at "Acta tropica"
DOI: 10.1016/j.actatropica.2021.106152
Abstract: Escaping the complement system is an important step in the establishment of infections. Some pathogens have acquired the ability to inactivate the complement system to ensure successful infection. This has been observed in parasites from… read more here.
Keywords: complement regulatory; complement system; complement; factor ... See more keywords
Evaluation of complement system proteins C3a, C5a and C6 in patients of endometriosis.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical biochemistry"
DOI: 10.1016/j.clinbiochem.2020.04.005
Abstract: BACKGROUND Endometriosis is a disease that shows auto-immune and chronic characteristics, suggesting a role for proteins mediating immune interactions in its pathophysiology. The aim was to evaluate C3a and C5a for their role in inflammatory… read more here.
Keywords: endometriosis; proteins c3a; complement system; c3a c5a ... See more keywords
A comparative approach on the activation of the three complement system pathways in different hosts of Visceral Leishmaniasis after stimulation with Leishmania infantum.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental and comparative immunology"
DOI: 10.1016/j.dci.2021.104061
Abstract: Visceral Leishmaniasis is an infectious disease that affects mainly humans and dogs, with the latter being important reservoirs of the parasite. Conversely, cats are naturally resistant. The immune system can offer important explanation to this… read more here.
Keywords: system; complement system; visceral leishmaniasis; complement ... See more keywords
Role of complement system in patients with biopsy-proven immunoglobulin G4-related kidney disease.
Sign Up to like & getrecommendations! Published in 2018 at "Human pathology"
DOI: 10.1016/j.humpath.2018.07.008
Abstract: Hypocomplementemia has been frequently reported in immunoglobulin G4-related kidney disease (IgG4-RKD). However, studies on the role of complement system in IgG4-RKD are lacking. A total of 40 429 renal biopsies from January 2010 to January 2018… read more here.
Keywords: immunoglobulin related; serum; complement system; igg4 rkd ... See more keywords
Complement system deregulation in SAPHO syndrome revealed by proteomic profiling.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2021.104399
Abstract: SAPHO syndrome is an inflammatory disease invading the skin and bones, whose diagnosis has been difficult due to its low incidence and diversified manifestation. We investigated the serum proteomic profile of SAPHO patients to identify… read more here.
Keywords: sapho patients; cfh c4bp; complement system; sapho syndrome ... See more keywords
The complement system in age-related macular degeneration: A review of rare genetic variants and implications for personalized treatment
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Immunology"
DOI: 10.1016/j.molimm.2016.11.016
Abstract: HighlightsThe complement system plays a central role in age‐related macular degeneration (AMD).Common and rare genetic variants in complement genes have been identified in AMD.Several of the rare variants affect the functioning of the complement system.However,… read more here.
Keywords: age related; related macular; complement system; complement ... See more keywords