Inhibition of thrombin activity by a covalent-binding aptamer and reversal by the complementary strand antidote.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d0cc08109d
Abstract: Alleviating the potential risk of irreversible adverse drug effects has been an important and challenging issue for the development of covalent drugs. Here we created a DNA-aptamer-type covalent drug by introducing a sulfonyl fluoride warhead… read more here.
Keywords: binding aptamer; strand antidote; covalent; complementary strand ... See more keywords
Points of View on the Tools for Genome/Gene Editing
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22189872
Abstract: Theoretically, a DNA sequence-specific recognition protein that can distinguish a DNA sequence equal to or more than 16 bp could be unique to mammalian genomes. Long-sequence-specific nucleases, such as naturally occurring Homing Endonucleases and artificially… read more here.
Keywords: cas9 sgrna; breakage; target; complementary strand ... See more keywords