Complete deconvolution of cellular mixtures based on linearity of transcriptional signatures
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09990-5
Abstract: Changes in bulk transcriptional profiles of heterogeneous samples often reflect changes in proportions of individual cell types. Several robust techniques have been developed to dissect the composition of such mixed samples given transcriptional signatures of… read more here.
Keywords: transcriptional signatures; complete deconvolution; cellular mixtures; deconvolution cellular ... See more keywords
CDSeq: A novel complete deconvolution method for dissecting heterogeneous samples using gene expression data
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1007510
Abstract: Quantifying cell-type proportions and their corresponding gene expression profiles in tissue samples would enhance understanding of the contributions of individual cell types to the physiological states of the tissue. Current approaches that address tissue heterogeneity… read more here.
Keywords: complete deconvolution; expression; deconvolution; cell ... See more keywords