Aquaporin 4 knockout increases complete freund's adjuvant-induced spinal central sensitization
Sign Up to like & getrecommendations! Published in 2020 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2020.01.004
Abstract: Growing evidence suggests a critical role of astrocytes for pain regulation. The water channel protein aquaporin 4 (AQP4), a functional regulator of astrocytes, is involved in various neurological disorders. However, the pathophysiological roles of AQP4… read more here.
Keywords: spinal central; central sensitization; complete freund; induced spinal ... See more keywords
Effects of dexamethasone and acetylsalicylic acid on inflammation caused by Complete Freund's adjuvant in the naked mole rat (Heterocephalus glaber)
Sign Up to like & getrecommendations! Published in 2022 at "Heliyon"
DOI: 10.1016/j.heliyon.2022.e08920
Abstract: The naked mole rat (NMR) is a fossorial rodent that has been observed to have a unique nociceptive system in comparison to others. In this study, we explored on characterization of chronic inflammation in the… read more here.
Keywords: naked mole; acetylsalicylic acid; complete freund; dexamethasone acetylsalicylic ... See more keywords
Sarcococca saligna Hydroalcoholic Extract Ameliorates Arthritis in Complete Freund’s Adjuvant-Induced Arthritic Rats via Modulation of Inflammatory Biomarkers and Suppression of Oxidative Stress Markers
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DOI: 10.1021/acsomega.2c00619
Abstract: Traditionally, Sarcococca saligna has been used for the treatment of arthritis and many other inflammatory disorders. The current study was planned to give scientific evidence to this traditional use of S. saligna. Phytochemical profiling of… read more here.
Keywords: extract; ssme; complete freund; oxidative stress ... See more keywords
Synthetic mycobacterial molecular patterns partially complete Freund’s adjuvant
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DOI: 10.1038/s41598-020-62543-5
Abstract: Complete Freund’s adjuvant (CFA) has historically been one of the most useful tools of immunologists. Essentially comprised of dead mycobacteria and mineral oil, we asked ourselves what is special about the mycobacterial part of this… read more here.
Keywords: molecular patterns; complete freund; freund adjuvant; synthetic mycobacterial ... See more keywords
Pra-C exerts analgesic effect through inhibiting microglial activation in anterior cingulate cortex in complete Freund’s adjuvant-induced mouse model
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Pain"
DOI: 10.1177/1744806921990934
Abstract: Chronic pain is highly prevalent worldwide and severely affects daily lives of patients and family members. Praeruptorin C (Pra-C) is a main active ingredient derived from Peucedanum praeruptorum Dunn, traditionally used as antibechic, anti-bronchitis and… read more here.
Keywords: pra; effect; complete freund; activation ... See more keywords
Effects of different doses of complete Freund’s adjuvant on nociceptive behaviour and inflammatory parameters in polyarthritic rat model mimicking rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0260423
Abstract: Complete Freund’s adjuvant (CFA) has been used to develop the arthritic or inflammatory condition in the animal, but there is a lack of information concerning high CFA doses on nociceptive behaviour and inflammatory parameters. This… read more here.
Keywords: cfa; complete freund; inflammatory; rat ... See more keywords
Dehydrozingerone Alleviates Hyperalgesia, Oxidative Stress and Inflammatory Factors in Complete Freund’s Adjuvant-Induced Arthritic Rats
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DOI: 10.2147/dddt.s374827
Abstract: Purpose Rheumatoid arthritis (RA) is a chronic autoimmune disease with severe inflammatory responses. Dehydrozingerone (DHZ) is a potent bioactive compound found in the rhizomes of Zingiber officinale, and it has been reported as an excellent… read more here.
Keywords: factor; complete freund; oxidative stress; freund adjuvant ... See more keywords
Puerarin Attenuates Complete Freund’s Adjuvant-Induced Trigeminal Neuralgia and Inflammation in a Mouse Model via Sirt1-Mediated TGF-β1/Smad3 Inhibition
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DOI: 10.2147/jpr.s323588
Abstract: Background Puerarin, an active compound of radix puerariae, is a major compound used in Chinese herbal medicines and it has been well known for its pharmacological effects, including antioxidant, anti‑inflammatory, neuroprotective and cardioprotective properties. The… read more here.
Keywords: induced trigeminal; freund adjuvant; trigeminal neuralgia; complete freund ... See more keywords
Butin Attenuates Arthritis in Complete Freund’s Adjuvant-Treated Arthritic Rats: Possibly Mediated by Its Antioxidant and Anti-Inflammatory Actions
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.810052
Abstract: The present research work was planned to evaluate the antioxidant and anti-inflammatory actions of butin in preventing complete Freund’s adjuvant-induced arthritis in rats. Adult Wistar rats (200–240 g) were segregated equally into four groups: Group… read more here.
Keywords: group; complete freund; freund adjuvant; anti inflammatory ... See more keywords
Decrease of IL-1β and TNF in the Spinal Cord Mediates Analgesia Produced by Ankle Joint Mobilization in Complete Freund Adjuvant-Induced Inflammation Mice Model
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.816624
Abstract: Objective This study aims to investigate the effects of ankle joint mobilization (AJM) on mechanical hyperalgesia and peripheral and central inflammatory biomarkers after intraplantar (i.pl.) Complete Freund’s Adjuvant (CFA)-induced inflammation. Methods Male Swiss mice were… read more here.
Keywords: ankle joint; joint mobilization; inflammation; complete freund ... See more keywords
NLRP2 Is Overexpressed in Spinal Astrocytes at the Peak of Mechanical Pain Sensitivity during Complete Freund Adjuvant-Induced Persistent Pain
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms222111408
Abstract: Our earlier findings revealed that interleukin-1 receptor type-1 (IL-1R1) was overexpressed in spinal neurons, and IL-1R1-deficient mice showed significant attenuation of thermal and mechanical allodynia during the course of the Complete Freund adjuvant (CFA)-induced persistent… read more here.
Keywords: persistent pain; overexpressed spinal; complete freund; freund adjuvant ... See more keywords