Completing gene trees without species trees in sub-quadratic time
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btab875
Abstract: MOTIVATION As genome-wide reconstruction of phylogenetic trees becomes more widespread, limitations of available data are being appreciated more than ever before. One issue is that phylogenomic datasets are riddled with missing data, and gene trees,… read more here.
Keywords: complete gene; time; gene trees; trees without ... See more keywords
A CRISPR-del-based pipeline for complete gene knockout in human diploid cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cell Science"
DOI: 10.1242/jcs.260000
Abstract: The advance of CRISPR/Cas9 technology has enabled us easily to generate gene knockout cell lines by introducing insertion/deletion mutations (indels) at the target site via the error-prone non-homologous end joining repair system. Frameshift-promoting indels can… read more here.
Keywords: complete gene; gene knockout; crispr del; human diploid ... See more keywords