Causative Mutations and Mechanism of Androgenetic Hydatidiform Moles.
Sign Up to like & getrecommendations! Published in 2018 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2018.10.007
Abstract: Androgenetic complete hydatidiform moles are human pregnancies with no embryos and affect 1 in every 1,400 pregnancies. They have mostly androgenetic monospermic genomes with all the chromosomes originating from a haploid sperm and no maternal… read more here.
Keywords: mutations mechanism; hydatidiform; androgenetic complete; complete hydatidiform ... See more keywords
Loss of X Chromosome Inactivation in Androgenetic Complete Hydatidiform Moles With 46, XX Karyotype
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DOI: 10.1097/pgp.0000000000000697
Abstract: Most complete hydatidiform moles (CHMs) showcase an androgenetic nature of the nuclear genome. In the normal female embryo, one of the 2 X chromosomes is inactive. However, the status of X chromosome inactivation (XCI) in… read more here.
Keywords: expression; androgenetic chms; complete hydatidiform; normal female ... See more keywords
ABO blood type compatibility is not a risk factor for gestational trophoblastic neoplasia development from androgenetic complete hydatidiform moles
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Reproductive Immunology"
DOI: 10.1111/aji.13237
Abstract: Complete hydatidiform moles (CHMs) are allografts to patients in terms of an androgenetic origin. Thus, some immunological reactions may be involved in the development of gestational trophoblastic neoplasia (GTN) from CHMs. This study aimed to… read more here.
Keywords: abo blood; gestational trophoblastic; complete hydatidiform; hydatidiform moles ... See more keywords
Management of a complete hydatidiform mole with a coexisting live fetus followed by successful treatment of maternal metastatic gestational trophoblastic disease: learning points
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DOI: 10.1136/bcr-2020-235028
Abstract: A 34-year-old patient had her first trimester Down syndrome scan followed by serial ultrasound scans which showed a single intrauterine pregnancy with multiple cystic areas in the anterior placenta. She presented in preterm labour with… read more here.
Keywords: gestational trophoblastic; complete hydatidiform; mole; trophoblastic disease ... See more keywords
Centralized surveillance of hydatidiform mole: 7-year experience from a regional hospital in China
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Gynecological Cancer"
DOI: 10.1136/ijgc-2021-002797
Abstract: Objective To assess the strategy and value of centralized surveillance of hydatidiform mole at a regional hospital in China and to investigate the necessity of prophylactic chemotherapy for high-risk complete hydatidiform mole. Methods Between February… read more here.
Keywords: risk; trophoblastic neoplasia; surveillance; hydatidiform ... See more keywords
Comparison of different therapeutic strategies for complete hydatidiform mole in women at least 40 years old: a retrospective cohort study
Sign Up to like & getrecommendations! Published in 2017 at "BMC Cancer"
DOI: 10.1186/s12885-017-3749-8
Abstract: BackgroundThere are three main therapeutic strategies, namely expectant management (dilation and curettage only), prophylactic chemotherapy and prophylactic total hysterectomy for treating older women with complete hydatidiform mole (CHM). However, the scientific community has so far,… read more here.
Keywords: years old; group; least years; therapeutic strategies ... See more keywords
Expression of Pro-Apoptotic Bax and Anti-Apoptotic Bcl-2 Proteins in Hydatidiform Moles and Placentas With Hydropic Changes
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DOI: 10.18502/acta.v57i1.1750
Abstract: Abstract- Morphologic examination still forms the main diagnostic tool in the differential diagnosis of molar placentas. However the criteria are subjective and show considerable inter-observer variability among pathologists. The aim of the present study was… read more here.
Keywords: partial hydatidiform; hydropic; complete hydatidiform; hydatidiform ... See more keywords
Whole-exome sequencing reveals genetic variants in ERC1 and KCNG4 associated with complete hydatidiform mole in Chinese Han women
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.20769
Abstract: Complete hydatidiform mole (CHM) is a rare pregnancy-related disease with invasive potential. The genetics underlying the sporadic form of CHM have not been addressed previously, but maternal genetic variants may be involved in biparental CHM.… read more here.
Keywords: exome sequencing; genetic variants; hydatidiform mole; complete hydatidiform ... See more keywords
Is Ki-67 of Diagnostic Value in Distinguishing Between Partial and Complete Hydatidiform Moles? A Systematic Review and Meta-analysis.
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DOI: 10.21873/anticanres.12329
Abstract: BACKGROUND/AIM To demonstrate the value of Ki-67 in distinguishing between partial and complete hydatidiform moles. MATERIALS AND METHODS We searched electronic databases included Medline, WOK, Cochrane Library and CNKI, through January 24, 2015. Experts were… read more here.
Keywords: partial complete; distinguishing partial; value distinguishing; hydatidiform ... See more keywords
Dysregulation of Placental Functions and Immune Pathways in Complete Hydatidiform Moles
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DOI: 10.3390/ijms20204999
Abstract: Gene expression studies of molar pregnancy have been limited to a small number of candidate loci. We analyzed high-dimensional RNA and protein data to characterize molecular features of complete hydatidiform moles (CHMs) and corresponding pathologic… read more here.
Keywords: immune pathways; complete hydatidiform; placental functions; dysregulation placental ... See more keywords