The heteromeric PC-1/PC-2 polycystin complex is activated by the PC-1 N-terminus
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DOI: 10.7554/elife.60684
Abstract: Mutations in the polycystin proteins, PC-1 and PC-2, result in autosomal dominant polycystic kidney disease (ADPKD) and ultimately renal failure. PC-1 and PC-2 enrich on primary cilia, where they are thought to form a heteromeric… read more here.
Keywords: polycystin; polycystin complex; activated terminus; complex activated ... See more keywords