Neuronal SNARE complex assembly guided by Munc18‐1 and Munc13‐1
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13394
Abstract: Neurotransmitter release by Ca2+‐triggered synaptic vesicle exocytosis is essential for information transmission in the nervous system. The soluble N‐ethylmaleimide sensitive factor attachment protein receptors (SNAREs) syntaxin‐1, SNAP‐25, and synaptobrevin‐2 form the SNARE complex to bring… read more here.
Keywords: complex assembly; neuronal snare; snare complex; munc18 munc13 ... See more keywords
Hepatic Suppression of Mitochondrial Complex II Assembly Drives Systemic Metabolic Benefits
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DOI: 10.1002/advs.202105587
Abstract: Abstract Alternate day fasting (ADF), the most popular form of caloric restriction, has shown to improve metabolic health in preclinical subjects, while intrinsic network underpinning the process remains unclear. Here, it is found that liver… read more here.
Keywords: complex assembly; hepatic suppression; mitochondrial complex; assembly ... See more keywords
ATG16L2 inhibits NLRP3 inflammasome activation through promoting ATG5‐12‐16L1 complex assembly and autophagy
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149764
Abstract: NLRP3 inflammasome activation is regulated by autophagy, a process tightly controlled by the ATG16L family proteins. However, the inside mechanisms remain elusive. Although the autophagy‐related protein ATG16L1 has been well characterized, regulation and biological functions… read more here.
Keywords: atg5 16l1; 16l1 complex; inflammasome activation; complex assembly ... See more keywords
Degradation of the mitochondrial complex I assembly factor TMEM126B under chronic hypoxia
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-018-2779-y
Abstract: Cell stress such as hypoxia elicits adaptive responses, also on the level of mitochondria, and in part is mediated by the hypoxia-inducible factor (HIF) 1α. Adaptation of mitochondria towards acute hypoxic conditions is reasonably well… read more here.
Keywords: chronic hypoxia; factor; assembly; hypoxia ... See more keywords
Androgens Induce Invasiveness of Triple Negative Breast Cancer Cells Through AR/Src/PI3-K Complex Assembly
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DOI: 10.1038/s41598-019-41016-4
Abstract: Breast cancer (BC) is still characterized by high morbidity and mortality. A specific BC subtype named triple negative BC (TNBC) lacks estrogen and progesterone receptors (ER and PR, respectively) and is characterized by the absence… read more here.
Keywords: breast cancer; assembly; invasiveness; triple negative ... See more keywords
Sideroflexin 4 is a complex I assembly factor that interacts with the MCIA complex and is required for the assembly of the ND2 module
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2115566119
Abstract: Significance Mitochondria are double-membraned eukaryotic organelles that house the proteins required for generation of ATP, the energy currency of cells. ATP generation within mitochondria is performed by five multisubunit complexes (complexes I to V), the… read more here.
Keywords: mitochondrial disease; sideroflexin complex; factor interacts; interacts mcia ... See more keywords
Cotranslational interaction of human EBP50 and ezrin overcomes masked binding site during complex assembly
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2115799119
Abstract: Significance Multiprotein complexes in mammalian cells are thought to form by interactions between domains of mature, fully folded proteins. However, in some cases interprotein interaction is obstructed by “buried” or inaccessible binding domains. One such… read more here.
Keywords: interaction; cotranslational interaction; complex assembly; site ... See more keywords
Asymmetric Rab activation of vacuolar HOPS to catalyze SNARE complex assembly
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e20-01-0019
Abstract: Intracellular membrane fusion requires Rab-family GTPases, their effector tethers, soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins, and SNARE chaperones of the Sec1/Munc18 (SM), Sec17/α-SNAP, and Sec18/NSF families. We have developed an assay using fluorescence… read more here.
Keywords: catalyze snare; snare; complex assembly; membrane ... See more keywords
Identification of defined structural elements within TOR2 kinase required for TOR complex 2 assembly and function in Saccharomyces cerevisiae
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e21-12-0611
Abstract: The mammalian target of rapamycin (mTOR) is a large protein kinase that assembles into two multisubunit protein complexes, mTORC1 and mTORC2, to regulate cell growth in eukaryotic cells. While significant progress has been made in… read more here.
Keywords: function; tor complex; tor; assembly ... See more keywords
SNARE assembly enlightened by cryo-EM structures of a synaptobrevin–Munc18-1–syntaxin-1 complex
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1101/2022.03.05.483126
Abstract: Munc18-1 forms a template to recruit and organize assembly of the SNARE complex that triggers neurotransmitter release, binding first to a closed conformation of syntaxin-1 where its N-terminal region interacts with the SNARE motif, and… read more here.
Keywords: snare; cryo structures; syntaxin; complex assembly ... See more keywords
NDUFAF3 variants that disrupt mitochondrial complex I assembly may associate with cavitating leukoencephalopathy
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Genetics"
DOI: 10.1111/cge.13215
Abstract: Genetic abnormalities in mitochondrial complex assembling factors are associated with leukoencephalopathy. We present a 1‐year‐old girl with consciousness disturbance after a respiratory infection. Brain MRI revealed leukoencephalopathy with bilaterally symmetrical hyperintensity in the substantia nigra,… read more here.
Keywords: disrupt mitochondrial; ndufaf3 variants; variants disrupt; complex ... See more keywords