Efficacy and safety of prothrombin complex concentrate for vitamin K antagonist-associated intracranial hemorrhage: a systematic review and meta-analysis
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DOI: 10.1007/s10072-019-3726-x
Abstract: BackgroundProthrombin complex concentrate (PCC) is the treatment of choice in vitamin K antagonist-associated intracranial hemorrhage (VKA-ICH). However, the efficiency and safety associated with their use remain unclear.AimsThis study aimed to assess the current evidence of… read more here.
Keywords: pcc; antagonist associated; vitamin antagonist; associated intracranial ... See more keywords
Initiation of a fixed- dose four- factor prothrombin complex concentrate protocol
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DOI: 10.1007/s11239-019-02020-7
Abstract: We read with much interest the article “Initiation of a fixeddose fourfactor prothrombin complex concentrate protocol” published by Fuh. L et al. in your esteemed journal. In this study, authors have included 63 patients with… read more here.
Keywords: administration; inr; administration pcc; prothrombin complex ... See more keywords
COLLABORATIVE PRESCRIBING OF FOUR-FACTOR PROTHROMBIN COMPLEX CONCENTRATE FOR EMERGENT ANTICOAGULATION REVERSAL
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DOI: 10.1016/s0735-1097(19)32742-1
Abstract: Emergent reversal of oral anticoagulation (OAC), including vitamin K antagonist (VKA) and direct-acting oral anticoagulant (DOAC) therapy, continues to be an important aspect of OAC due to the potential for serious bleeding events. Four-factor prothrombin… read more here.
Keywords: reversal; complex concentrate; emergent; factor prothrombin ... See more keywords
Real-life experiences with goal-directed prohemostatic therapy with fibrinogen concentrate, prothrombin complex concentrate, and recombinant factor VIIa: a retrospective study of 287 consecutive patients
Sign Up to like & getrecommendations! Published in 2022 at "Scandinavian Journal of Clinical and Laboratory Investigation"
DOI: 10.1080/00365513.2022.2040048
Abstract: Abstract The Danish Capital Region Blood Bank operates a 24/7 on-call service staffed with physicians specialized in hemostatic management to guide clinicians in hemostatic resuscitation, including administration of prohemostatic therapy (PHT). The outcome of patients… read more here.
Keywords: complex concentrate; fibrinogen concentrate; concentrate; recombinant factor ... See more keywords
Comparison of outcomes in patients with intracranial hemorrhage on factor Xa inhibitors versus vitamin K antagonists treated with 4-factor prothrombin complex concentrate
Sign Up to like & getrecommendations! Published in 2018 at "Baylor University Medical Center Proceedings"
DOI: 10.1080/08998280.2018.1440858
Abstract: ABSTRACT The relative clinical efficacy of 4-factor prothrombin complex concentrate (4F-PCC) in oral anticoagulant–associated intracranial hemorrhage is unknown, especially for factor Xa–inhibiting anticoagulants. We report short-term outcomes of patients with oral anticoagulant–associated intracranial hemorrhage on… read more here.
Keywords: intracranial hemorrhage; hemorrhage; prothrombin complex; factor ... See more keywords
551: SINGLE-INSTITUTION COMPARISON OF 4-FACTOR PROTHROMBIN COMPLEX CONCENTRATE VERSUS FRESH FROZEN PLASMA
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DOI: 10.1097/01.ccm.0000528568.22798.ca
Abstract: www.ccmjournal.org Critical Care Medicine • Volume 46 • Number 1 (Supplement) Learning Objectives: Randomized controlled trials have found four-factor prothrombin complex concentrate (4F-PCC) to be as effective as fresh frozen plasma (FFP) for acute reversal… read more here.
Keywords: medicine; fresh frozen; versus; prothrombin complex ... See more keywords
564: CHARACTERIZING THE USE OF 4-FACTOR PROTHROMBIN COMPLEX CONCENTRATE
Sign Up to like & getrecommendations! Published in 2018 at "Critical Care Medicine"
DOI: 10.1097/01.ccm.0000528580.60916.80
Abstract: www.ccmjournal.org Critical Care Medicine • Volume 46 • Number 1 (Supplement) Learning Objectives: Off-label medication use is common in critically ill patients in the United States. Kcentra® is a 4-factor prothrombin complex concentrate (4PCC) approved… read more here.
Keywords: medicine; use; prothrombin complex; factor prothrombin ... See more keywords
Prothrombin Complex Concentrate Use in Durable and Short-Term Left Ventricular Assist Device Implantation
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DOI: 10.1097/mat.0000000000000937
Abstract: Supplemental Digital Content is available in the text. read more here.
Keywords: concentrate use; durable short; complex concentrate; short term ... See more keywords
Activated prothrombin complex concentrate to treat bleeding events in acquired hemophilia A: BAHAS study
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DOI: 10.1111/ejh.13853
Abstract: Activated prothrombin complex concentrate (aPCC) is a bypassing agent indicated to treat bleeds in patients with acquired hemophilia A (AHA). Nevertheless, its efficacy and safety in the real‐world setting have not often been addressed. read more here.
Keywords: complex concentrate; prothrombin complex; activated prothrombin; acquired hemophilia ... See more keywords
Safety of FEIBA and emicizumab (SAFE): Dose escalation study evaluating the safety of in vivo administration of activated prothrombin complex concentrate in haemophilia A patients on emicizumab
Sign Up to like & getrecommendations! Published in 2022 at "Haemophilia"
DOI: 10.1111/hae.14684
Abstract: Emicizumab is a humanized bispecific monoclonal antibody licensed for patients with severe haemophilia A. Breakthrough bleeding still occurs in patients on emicizumab and can be managed with recombinant factor VIIa (rFVIIa) or activated prothrombin complex… read more here.
Keywords: safety; complex concentrate; patients emicizumab; prothrombin complex ... See more keywords
On‐label compared to off‐label four‐factor prothrombin complex concentrate use: a retrospective, observational study
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DOI: 10.1111/trf.15355
Abstract: Four‐factor prothrombin complex concentrate (4F‐PCC) is US Food and Drug Administration approved for the urgent reversal of coagulation factor deficiency induced by a vitamin K antagonist complicated by acute major bleeding or in situations in… read more here.
Keywords: four factor; prothrombin complex; factor; factor prothrombin ... See more keywords