Photoreactivity of C=N Double Bond Using N‐(4‐Pyridylmethylene)aniline‐coordinated Zn(II) Complex Crystal
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DOI: 10.1002/ejic.202400272
Abstract: The photoirradiation to the Zn complex crystal having N‐(4‐pyridylmethylene)aniline (4‐pma) ligand with a central ‐C=N‐ bond led to no photodimerization reaction but only partial trans‐cis isomerization of 4‐pma. The reason why no photodimerization reaction occurred… read more here.
Keywords: pyridylmethylene aniline; complex crystal; bond; photoreactivity double ... See more keywords
Complex Crystal Structure Determination and in vitro Anti–non–small Cell Lung Cancer Activity of Hsp90N Inhibitor SNX-2112
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DOI: 10.3389/fcell.2021.650106
Abstract: SNX-2112, as a promising anticancer lead compound targeting heat shock protein 90 (Hsp90), absence of complex crystal structure of Hsp90N-SNX-2112 hindered further structural optimization and understanding on molecular interaction mechanism. Herein, a high-resolution complex crystal… read more here.
Keywords: crystal structure; cell; complex crystal; snx 2112 ... See more keywords
Complex Crystal Structure Determination of Hsp90N-NVP-AUY922 and In Vitro Anti-NSCLC Activity of NVP-AUY922
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DOI: 10.3389/fonc.2022.847556
Abstract: New targeted chemotherapy agents greatly improved five-year survival in NSCLC patients, but which were susceptible to drug resistance. NVP-AUY922, terminated in phase II clinical trials, exhibited promising anti-NSCLC (non-small-cell lung cancer) activity targeting to Hsp90N… read more here.
Keywords: hsp90n; nvp auy922; complex crystal; auy922 ... See more keywords