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1
Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.650106
Abstract: SNX-2112, as a promising anticancer lead compound targeting heat shock protein 90 (Hsp90), absence of complex crystal structure of Hsp90N-SNX-2112 hindered further structural optimization and understanding on molecular interaction mechanism. Herein, a high-resolution complex crystal…
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Keywords:
crystal structure;
cell;
complex crystal;
snx 2112 ... See more keywords
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2
Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.847556
Abstract: New targeted chemotherapy agents greatly improved five-year survival in NSCLC patients, but which were susceptible to drug resistance. NVP-AUY922, terminated in phase II clinical trials, exhibited promising anti-NSCLC (non-small-cell lung cancer) activity targeting to Hsp90N…
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Keywords:
hsp90n;
nvp auy922;
complex crystal;
auy922 ... See more keywords