Multi-Omic Approaches to Identify Genetic Factors in Metabolic Syndrome.
Sign Up to like & getrecommendations! Published in 2021 at "Comprehensive Physiology"
DOI: 10.1002/cphy.c210010
Abstract: Metabolic syndrome (MetS) is a highly heritable disease and a major public health burden worldwide. MetS diagnosis criteria are met by the simultaneous presence of any three of the following: high triglycerides, low HDL/high LDL… read more here.
Keywords: complex disease; omic approaches; approaches identify; disease ... See more keywords
Improved growth, tolerance and intake with an extensively hydrolysed peptide feed in infants with complex disease.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical nutrition"
DOI: 10.1016/j.clnu.2017.04.012
Abstract: BACKGROUND & AIMS Infants with complex medical conditions often display faltering growth due to elevated nutritional requirements, poor intake and intolerance of feeding with malabsorption and maldigestion. As a result their nutritional management can be… read more here.
Keywords: peptide feed; complex disease; study; growth ... See more keywords
FunVar: A systematic pipeline to unravel the convergence patterns of genetic variants in ASD, a paradigmatic complex disease
Sign Up to like & getrecommendations! Published in 2019 at "Journal of biomedical informatics"
DOI: 10.1016/j.jbi.2019.103273
Abstract: In recent years, the technological advances for capturing genetic variation in large populations led to the identification of large numbers of putative or disease-causing variants. However, their mechanistic understanding is lagging far behind and has… read more here.
Keywords: systematic pipeline; pipeline; complex disease; genetic variants ... See more keywords
Modelling the genetic aetiology of complex disease: human–mouse conservation of noncoding features and disease-associated loci
Sign Up to like & getrecommendations! Published in 2022 at "Biology Letters"
DOI: 10.1098/rsbl.2021.0630
Abstract: Understanding the genetic aetiology of loci associated with a disease is crucial for developing preventative measures and effective treatments. Mouse models are used extensively to understand human pathobiology and mechanistic functions of disease-associated loci. However,… read more here.
Keywords: complex disease; disease; associated loci; genetic aetiology ... See more keywords
Using Full Genomic Information to Predict Disease: Breaking Down the Barriers Between Complex and Mendelian Diseases.
Sign Up to like & getrecommendations! Published in 2018 at "Annual review of genomics and human genetics"
DOI: 10.1146/annurev-genom-083117-021136
Abstract: While sequence-based genetic tests have long been available for specific loci, especially for Mendelian disease, the rapidly falling costs of genome-wide genotyping arrays, whole-exome sequencing, and whole-genome sequencing are moving us toward a future where… read more here.
Keywords: using full; genomic information; complex disease; disease ... See more keywords
Comparative genomic analysis of Mycobacterium intracellulare: implications for clinical taxonomic classification in pulmonary Mycobacterium avium-intracellulare complex disease
Sign Up to like & getrecommendations! Published in 2021 at "BMC Microbiology"
DOI: 10.1186/s12866-021-02163-9
Abstract: Background Mycobacterium intracellulare is a representative etiological agent of emerging pulmonary M. avium-intracellulare complex disease in the industrialized countries worldwide. The recent genome sequencing of clinical strains isolated from pulmonary M. avium-intracellulare complex disease has… read more here.
Keywords: mycobacterium; complex disease; comparative genomic; intracellulare ... See more keywords
A Model of Compound Heterozygous, Loss-of-Function Alleles Is Broadly Consistent with Observations from Complex-Disease GWAS Datasets
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1006573
Abstract: The genetic component of complex disease risk in humans remains largely unexplained. A corollary is that the allelic spectrum of genetic variants contributing to complex disease risk is unknown. Theoretical models that relate population genetic… read more here.
Keywords: model compound; complex disease; disease risk; disease ... See more keywords