Characterization of circular RNAs with advanced sequencing technologies in human complex diseases
Sign Up to like & getrecommendations! Published in 2022 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1759
Abstract: Circular RNAs (circRNAs) are one category of non‐coding RNAs that do not possess 5′ caps and 3′ free ends. Instead, they are derived in closed circle forms from pre‐mRNAs by a non‐canonical splicing mechanism named… read more here.
Keywords: advanced sequencing; full length; complex diseases; circular rnas ... See more keywords
Pleiotropic Effects of Risk Factors in Age-Related Macular Degeneration and Seemingly Unrelated Complex Diseases.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-75402-4_30
Abstract: Age-related macular degeneration (AMD) is a complex disease with both environmental and genetic factors influencing disease risk. Genome-wide case-control association studies, candidate gene analyses, and epidemiological studies reinforced the notion that AMD is predominantly a… read more here.
Keywords: risk; macular degeneration; age related; related macular ... See more keywords
In silico disease model: from simple networks to complex diseases
Sign Up to like & getrecommendations! Published in 2020 at "Animal Biotechnology"
DOI: 10.1016/b978-0-12-811710-1.00020-3
Abstract: Abstract In this chapter we consider in silico modeling of diseases starting from some simple to some complex (and mathematical) concepts. Examples and applications of in silico modeling for some important categories of diseases (such… read more here.
Keywords: silico disease; model simple; disease model; simple networks ... See more keywords
[Children's medically complex diseases unit. A model required in all our hospitals].
Sign Up to like & getrecommendations! Published in 2018 at "Anales De Pediatria"
DOI: 10.1016/j.anpede.2017.04.004
Abstract: Abstract Introduction The increase in survival of children with severe diseases has led to the rise of children with chronic diseases, sometimes with lifelong disabilities. In 2008, a unit for the specific care of medically… read more here.
Keywords: medically complex; unit; unit model; complex diseases ... See more keywords
Imaging and future perspectives for diagnosis of complex diseases
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Epidemiology and Global Health"
DOI: 10.1016/j.cegh.2020.04.001
Abstract: Abstract Visual representation of anatomy, structure and physiology of our internal body forms a basis for therapeutic industry and medical research. Despite technological advancement in the medical field still the diagnosis of complex disease like… read more here.
Keywords: medicine; diagnosis complex; perspectives diagnosis; future perspectives ... See more keywords
The impact of non-additive genetic associations on age-related complex diseases
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-21952-4
Abstract: Genome-wide association studies (GWAS) are not fully comprehensive, as current strategies typically test only the additive model, exclude the X chromosome, and use only one reference panel for genotype imputation. We implement an extensive GWAS… read more here.
Keywords: age related; complex diseases; impact non; additive model ... See more keywords
What are the challenges with multi-targeted drug design for complex diseases?
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2022.2072827
Abstract: ABSTRACT Introduction Current findings on multifactorial diseases with a complex pathomechanism confirm that multi-target drugs are more efficient ways in treating them as opposed to single-target drugs. However, to design multi-target ligands, a number of… read more here.
Keywords: complex diseases; target drugs; design; drug ... See more keywords
Microbes and complex diseases: from experimental results to computational models
Sign Up to like & getrecommendations! Published in 2021 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbaa158
Abstract: Studies have shown that the number of microbes in humans is almost 10 times that of cells. These microbes have been proven to play an important role in a variety of physiological processes, such as… read more here.
Keywords: diseases experimental; experimental results; complex diseases; based models ... See more keywords
Identifying the critical states of complex diseases by the dynamic change of multivariate distribution
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac177
Abstract: The dynamics of complex diseases are not always smooth; they are occasionally abrupt, i.e. there is a critical state transition or tipping point at which the disease undergoes a sudden qualitative shift. There are generally… read more here.
Keywords: identifying critical; critical state; complex diseases; critical states ... See more keywords
Updated review of advances in microRNAs and complex diseases: experimental results, databases, webservers and data fusion
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac397
Abstract: MicroRNAs (miRNAs) are gene regulators involved in the pathogenesis of complex diseases such as cancers, and thus serve as potential diagnostic markers and therapeutic targets. The prerequisite for designing effective miRNA therapies is accurate discovery… read more here.
Keywords: fusion; complex diseases; review; updated review ... See more keywords
A comprehensive review on knowledge graphs for complex diseases
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac543
Abstract: In recent years, knowledge graphs (KGs) have gained a great deal of popularity as a tool for storing relationships between entities and for performing higher level reasoning. KGs in biomedicine and clinical practice aim to… read more here.
Keywords: comprehensive review; review knowledge; knowledge graphs; complex diseases ... See more keywords