Targeted Integration of Complex Genetic Elements at Multi-Copy Loci by Golden Gate Assembly.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0868-5_11
Abstract: Budding yeast Saccharomyces cerevisiae has become a model eukaryotic microorganism for targeted genomic manipulation due to its efficient homologous recombination. A few genomic loci, including rDNA, Delta, and Ty1, can be utilized to introduce variable… read more here.
Keywords: copy; gate assembly; genetic elements; complex genetic ... See more keywords
Joint association analysis method to dissect complex genetic architecture of multiple genetically related traits
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DOI: 10.1016/j.cj.2020.06.007
Abstract: Abstract Genome-wide association study (GWAS) has been a standard approach to discover the genetic determinants underlying complex traits. It is a major challenge in GWAS how to improve analysis power, uncover complex genetic correlation, and… read more here.
Keywords: related traits; multiple genetically; analysis; method ... See more keywords
Returning complex genetic risk information to promote better health-related behaviors: a commentary of the literature and suggested next steps.
Sign Up to like & getrecommendations! Published in 2022 at "Translational behavioral medicine"
DOI: 10.1093/tbm/ibac071
Abstract: Genome-wide association studies aim to identify genetic variants that are associated with a disease phenotype in order to enhance precision medicine efforts. Despite the excitement surrounding the promise of precision medicine and interest among the… read more here.
Keywords: information; risk information; complex genetic; medicine ... See more keywords
Complex genetic dependencies among growth and neurological phenotypes in healthy children: Towards deciphering developmental mechanisms
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DOI: 10.1371/journal.pone.0242684
Abstract: The genetic mechanisms of childhood development in its many facets remain largely undeciphered. In the population of healthy infants studied in the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) program, we have identified a… read more here.
Keywords: genetic dependencies; dependencies among; complex genetic; growth ... See more keywords
Neurodevelopmental Disorders in Patients With Complex Phenotypes and Potential Complex Genetic Basis Involving Non-Coding Genes, and Double CNVs
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DOI: 10.3389/fgene.2021.732002
Abstract: Neurodevelopmental disorders (NDDs) are a heterogeneous class of brain diseases, with a complex genetic basis estimated to account for up to 50% of cases. Nevertheless, genetic diagnostic yield is about 20%. Array-comparative genomic hybridization (array-CGH)… read more here.
Keywords: genetic basis; non coding; cnvs; complex genetic ... See more keywords