Disentangling complex genomic signals to understand population structure of an exploited, estuarine‐dependent flatfish
Sign Up to like & getrecommendations! Published in 2021 at "Ecology and Evolution"
DOI: 10.1002/ece3.8064
Abstract: Abstract Interpreting contemporary patterns of population structure requires an understanding of the interactions among microevolutionary forces and past demographic events. Here, 4,122 SNP‐containing loci were used to assess structure in southern flounder (Paralichthys lethostigma) sampled… read more here.
Keywords: complex genomic; population structure; structure; disentangling complex ... See more keywords
Identification of a complex genomic rearrangement in TMPRSS3 by massively parallel sequencing in Chinese cases with prelingual hearing loss
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.685
Abstract: Genetic variants in TMPRSS3 have been causally linked to autosomal recessive nonsyndromic hearing loss (HL) at the DFNB8 and DFNB10 loci. These variants include both single nucleotide and copy number variations (CNVs). In this study,… read more here.
Keywords: hearing loss; complex genomic; identification complex; genomic rearrangement ... See more keywords
Complete lung agenesis caused by complex genomic rearrangements with neo-TAD formation at the SHH locus
Sign Up to like & getrecommendations! Published in 2021 at "Human Genetics"
DOI: 10.1007/s00439-021-02344-6
Abstract: During human organogenesis, lung development is a timely and tightly regulated developmental process under the control of a large number of signaling molecules. Understanding how genetic variants can disturb normal lung development causing different lung… read more here.
Keywords: agenesis; complex genomic; shh locus; lung ... See more keywords
Comparative study on the induction of complex genomic alterations after exposure of mammalian cells to carboplatin and oxaliplatin
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DOI: 10.1080/01480545.2016.1252918
Abstract: Abstract Metal complexes are still broadly used as the first line of the treatment for different types of tumors nowadays. Carboplatin and oxaliplatin were authorized for clinical use, even though there is little information on… read more here.
Keywords: genomic alterations; complex genomic; induction complex; study ... See more keywords
Polycomb Repressor Complex 2 in Genomic Instability and Cancer
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DOI: 10.3390/ijms18081657
Abstract: Polycomb repressor complexes PRC1 and PRC2 regulate chromatin compaction and gene expression, and are widely recognized for their fundamental contributions to developmental processes. Herein, we summarize the existing evidence and molecular mechanisms linking PRC-mediated epigenetic… read more here.
Keywords: polycomb repressor; repressor complex; genomic instability; complex genomic ... See more keywords