Structural characterization of 14-3-3ζ in complex with the human Son of sevenless homolog 1 (SOS1).
Sign Up to like & getrecommendations! Published in 2018 at "Journal of structural biology"
DOI: 10.1016/j.jsb.2018.01.011
Abstract: The deviant Ras activation machinery is found in approximately 30% of all human cancers. SOS1 is an important protagonist of this pathway that plays a key-role in aberrant cell proliferation and differentiation. Interaction of SOS1… read more here.
Keywords: complex human; son sevenless; human son; sos1 ... See more keywords
Generation of complex human organoid models including vascular networks by incorporation of mesodermal progenitor cells
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-52204-7
Abstract: Organoids derived from human pluripotent stem cells are interesting models to study mechanisms of morphogenesis and promising platforms for disease modeling and drug screening. However, they mostly remain incomplete as they lack stroma, tissue resident… read more here.
Keywords: mesodermal progenitor; incorporation mesodermal; progenitor cells; complex human ... See more keywords
Novel Variance-Component TWAS method for studying complex human diseases with applications to Alzheimer’s dementia
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1009482
Abstract: Transcriptome-wide association studies (TWAS) have been widely used to integrate transcriptomic and genetic data to study complex human diseases. Within a test dataset lacking transcriptomic data, traditional two-stage TWAS methods first impute gene expression by… read more here.
Keywords: cis; complex human; level; variance ... See more keywords
Can Deep Learning Improve Genomic Prediction of Complex Human Traits?
Sign Up to like & getrecommendations! Published in 2018 at "Genetics"
DOI: 10.1534/genetics.118.301298
Abstract: The current excitement around artificial intelligence and the renewed interest in “deep learning” (DL) have been applied to the genetic analysis of complex traits; however, the performance of DL for genomic prediction of complex... The… read more here.
Keywords: complex human; prediction complex; genomic prediction; deep learning ... See more keywords
Microbiome or Infections: Amyloid-Containing Biofilms as a Trigger for Complex Human Diseases
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.638867
Abstract: The human microbiota is the community of microorganisms that live upon or within their human host. The microbiota consists of various microorganisms including bacteria, fungi, viruses, and archaea; the gut microbiota is comprised mostly of… read more here.
Keywords: complex human; curli; extracellular matrix; human amyloids ... See more keywords
Free-Ranging Dogs Are Capable of Utilizing Complex Human Pointing Cues
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Psychology"
DOI: 10.3389/fpsyg.2019.02818
Abstract: Dogs are one of the most common species to be found as pets and have been subjects of human curiosity, leading to extensive research on their socialization with humans. One of the dominant themes in… read more here.
Keywords: complex human; dogs capable; pointing cues; ranging dogs ... See more keywords