Defective Complex III Mitochondrial Respiratory Chain Due to A Novel Variant in CYC1 Gene Masquerades Acute Demyelinating Syndrome or Leber Hereditary Optic Neuropathy.
Sign Up to like & getrecommendations! Published in 2021 at "Mitochondrion"
DOI: 10.1016/j.mito.2021.07.001
Abstract: Complex III (CIII) is the third out of five mitochondrial respiratory chain complexes residing at the mitochondrial inner membrane. The assembly of 10 subunits encoded by nuclear DNA and one by mitochondrial DNA result in… read more here.
Keywords: mitochondrial respiratory; chain; respiratory chain; complex iii ... See more keywords
Rieske head domain dynamics and indazole-derivative inhibition of Candida albicans complex III.
Sign Up to like & getrecommendations! Published in 2021 at "Structure"
DOI: 10.1016/j.str.2021.08.006
Abstract: Electron transfer between respiratory complexes drives transmembrane proton translocation, which powers ATP synthesis and membrane transport. The homodimeric respiratory complex III (CIII2) oxidizes ubiquinol to ubiquinone, transferring electrons to cytochrome c and translocating protons through… read more here.
Keywords: head; rieske head; complex iii; head domain ... See more keywords
Verification of Resistance Mechanism of Mitochondrial Electron Transport Chain Complex III Inhibitors in Phytophthora sojae through Ectopic Overexpression.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.5c00747
Abstract: While Cytb point mutations are recognized as a contributing factor to the resistance of plant pathogens against mitochondrial electron transport chain (mETC) complex III inhibitors, there remains a notable absence of direct genetic transformation data.… read more here.
Keywords: resistance; iii; complex iii; mitochondrial electron ... See more keywords
Tryptophan Oxidation in the UQCRC1 Subunit of Mitochondrial Complex III (Ubiquinol-Cytochrome C Reductase) in a Mouse Model of Myodegeneration Causes Large Structural Changes in the Complex: A Molecular Dynamics Simulation Study
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-47018-6
Abstract: Muscle diseases display mitochondrial dysfunction and oxidative damage. Our previous study in a cardiotoxin model of myodegeneration correlated muscle damage with mitochondrial dysfunction, which in turn entailed altered mitochondrial proteome and oxidative damage of mitochondrial… read more here.
Keywords: iii; cytochrome reductase; complex iii; oxidation ... See more keywords
Potent inhibition of tumour cell proliferation and immunoregulatory function by mitochondria-targeted atovaquone
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-74808-0
Abstract: The FDA-approved prophylactic antimalarial drug atovaquone (ATO) recently was repurposed as an antitumor drug. Studies show that ATO exerts a profound antiproliferative effect in several cancer cells, including breast, ovarian, and glioma. Analogous to the… read more here.
Keywords: mitochondria targeted; potent inhibition; complex iii; ato ... See more keywords
NOX2-TRPM2 coupling promotes Zn2+ inhibition of complex III to exacerbate ROS production in a cellular model of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-66630-9
Abstract: Reactive oxygen species (ROS) serve vital physiological functions, but aberrant ROS production contributes to numerous diseases. Unfortunately, therapeutic progress targeting pathogenic ROS has been hindered by the limited understanding of whether the mechanisms driving pathogenic… read more here.
Keywords: ros; trpm2; complex iii; ros production ... See more keywords
Cancer Cell Mitochondria Targeting by Pancratistatin Analogs is Dependent on Functional Complex II and III
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep42957
Abstract: Enhanced mitochondrial stability and decreased dependence on oxidative phosphorylation confer an acquired resistance to apoptosis in cancer cells, but may present opportunities for therapeutic intervention. The compound pancratistatin (PST) has been shown to selectively induce… read more here.
Keywords: complex iii; cell mitochondria; cancer cells; cancer cell ... See more keywords
Myofibroblast differentiation and its functional properties are inhibited by nicotine and e-cigarette via mitochondrial OXPHOS complex III
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep43213
Abstract: Nicotine is the major stimulant in tobacco products including e-cigarettes. Fibroblast to myofibroblast differentiation is a key process during wound healing and is dysregulated in lung diseases. The role of nicotine and e-cigarette derived nicotine… read more here.
Keywords: myofibroblast differentiation; nicotine cigarette; differentiation; complex iii ... See more keywords
The cardiac-enriched microprotein mitolamban regulates mitochondrial respiratory complex assembly and function in mice
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2120476119
Abstract: Significance Microproteins are a growing class of versatile small proteins previously overlooked by standard gene annotation methods due to their small size. Here we characterize mitolamban as a cardiac-enriched inner mitochondrial membrane–localized microprotein, which interacts… read more here.
Keywords: iii; complex iii; assembly function; mice ... See more keywords
Inhibition of mitochondrial complex III or dihydroorotate dehydrogenase (DHODH) triggers formation of poly(A)+ RNA foci adjacent to nuclear speckles following activation of ATM (ataxia telangiectasia mutated)
Sign Up to like & getrecommendations! Published in 2022 at "RNA Biology"
DOI: 10.1080/15476286.2022.2146919
Abstract: ABSTRACT Intracellular and intercellular signalling networks play an essential role in optimizing cellular homoeostasis and are thought to be partly reflected in nuclear mRNA dynamics. However, the regulation of nuclear mRNA dynamics by intracellular and… read more here.
Keywords: rna; nuclear speckles; poly rna; complex iii ... See more keywords
Renal Tubular Mitochondrial Abnormalities in Complex II/III Respiratory Chain Deficiency
Sign Up to like & getrecommendations! Published in 2017 at "Fetal and Pediatric Pathology"
DOI: 10.1080/15513815.2017.1313916
Abstract: ABSTRACT Defects in the respiratory chain may present with a wide spectrum of clinical signs and symptoms. In this “Images in Pathology” discussion we correlate the clinical, histologic, and ultrastructural findings in a 12-year-old male… read more here.
Keywords: respiratory chain; complex iii; pathology; iii respiratory ... See more keywords