Entospletinib with decitabine in acute myeloid leukemia with mutant TP53 or complex karyotype: A phase 2 substudy of the Beat AML Master Trial.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer"
DOI: 10.1002/cncr.34780
Abstract: BACKGROUND Patients with acute myeloid leukemia (AML) who have tumor protein p53 (TP53) mutations or a complex karyotype have a poor prognosis, and hypomethylating agents are often used. The authors evaluated the efficacy of entospletinib,… read more here.
Keywords: myeloid leukemia; complex karyotype; substudy beat; karyotype ... See more keywords
ERG amplification is a secondary recurrent driver event in myeloid malignancy with complex karyotype and TP53 mutations
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.1002/gcc.23027
Abstract: ERG is a transcription factor encoded on chromosome 21q22.2 with important roles in hematopoiesis and oncogenesis of prostate cancer. ERG amplification has been identified as one of the most common recurrent events in acute myeloid… read more here.
Keywords: complex karyotype; amplification; driver event; erg amplification ... See more keywords
Prognostic impact of complex karyotype on post‐transplant outcomes of myelofibrosis
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DOI: 10.1002/hon.3058
Abstract: Chromosomal abnormalities in the role of prognostic factor for transplant patients with myelofibrosis (MF) are not fully investigated. Regarding complex karyotype (CK), we retrospectively analyzed 241 patients with primary and secondary MF who received a… read more here.
Keywords: transplant outcomes; complex karyotype; karyotype; group ... See more keywords
Adverse prognostic impact of complex karyotype (≥3 cytogenetic alterations) in adult T-cell acute lymphoblastic leukemia (T-ALL).
Sign Up to like & getrecommendations! Published in 2021 at "Leukemia research"
DOI: 10.1016/j.leukres.2021.106612
Abstract: The potential prognostic value of conventional karyotyping in adult T-cell acute lymphoblastic leukemia (T-ALL) remains an open question. We hypothesized that a modified cytogenetic classification, based on the number and type of cytogenetic abnormalities, would… read more here.
Keywords: cytogenetic alterations; cell acute; complex karyotype; lymphoblastic leukemia ... See more keywords
The transformation of isolated gastric myeloid sarcoma into acute myeloid leukemia presenting with a complex karyotype and TLS-ERG gene fusion
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000029475
Abstract: Abstract Rationale: Isolated myeloid sarcoma (MS) is characterized by the rapid proliferation of myeloblasts of acute myeloid leukemia (AML), without any blood or bone marrow involvement. This disease can manifest with extramedullary organ involvement, such… read more here.
Keywords: myeloid leukemia; complex karyotype; acute myeloid; karyotype tls ... See more keywords
Independent prognostic significance of TP53 mutations in adult acute myeloid leukaemia with complex karyotype
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DOI: 10.1111/ijlh.13864
Abstract: Adult acute myeloid leukaemia (AML) patients with complex karyotype (CK) generally have unfavourable outcomes. CK commonly co‐exists with characteristic chromosomal and genetic abnormalities such as monosomal karyotype (MK), −17 or 17p‐ [abn(17p)] and TP53 mutations.… read more here.
Keywords: complex karyotype; tp53 mutations; prognostic significance; acute myeloid ... See more keywords
Immunophenotypic dysplasia and aberrant T-cell antigen expression in acute myeloid leukaemia with complex karyotype and TP53 mutations
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Pathology"
DOI: 10.1136/jclinpath-2018-205348
Abstract: Aims Cytogenetic and molecular aberrations are the strongest factors in determining outcome in acute myeloid leukaemia (AML). AML with complex karyotype confers a particularly poor prognosis and is associated with morphologic dysplasia. Flow cytometric immunophenotyping… read more here.
Keywords: complex karyotype; karyotype; expression; immunophenotypic dysplasia ... See more keywords
A unique set of complex chromosomal abnormalities in an infant with myeloid leukemia associated with Down syndrome
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DOI: 10.1186/s13039-017-0335-3
Abstract: BackgroundChildren with Down syndrome (DS) have an enhanced risk of developing acute leukemia, with the most common subtype being acute megakaryoblastic leukemia (AMKL). Myeloid leukemia in Down syndrome (ML-DS) is considered a disease with distinct… read more here.
Keywords: complex karyotype; myeloid leukemia; unique set; set complex ... See more keywords
Genomic arrays for the identification of high-risk chronic lymphocytic leukemia: ready for prime time?
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DOI: 10.3324/haematol.2020.264689
Abstract: Hematopoietic tumors develop through the acquisition of multiple molecular cytogenetic lesions, which confer growth advantage to the neoplastic cells, favoring the emergence of clones resistant to treatment. Not surprisingly, a high number of chromosome aberrations… read more here.
Keywords: complex karyotype; lymphocytic leukemia; genomic arrays; chronic lymphocytic ... See more keywords
Case of Patient with AML with Complex Karyotype including Ultra-Rare t(4;8)(q32;q13), t(4;11)(q21;p15) and Familial Aggregation of Myeloid Malignancies
Sign Up to like & getrecommendations! Published in 2022 at "Medicina"
DOI: 10.3390/medicina58010105
Abstract: We present a unique case of a young woman with acute myeloid leukemia (AML) with complex karyotype. The presence of the t(4;11)(q23;p15) is extremely rare in myeloid leukemias, while t(4;8)(q32;q13) has not yet been described… read more here.
Keywords: q32 q13; aml complex; myeloid; complex karyotype ... See more keywords
A complex karyotype with t(11;12)(q23;p13) translocation with coexistent clones of deletion 5q and cryptic deletion 7q in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2020 at "Indian Journal of Cancer"
DOI: 10.4103/ijc.ijc_473_18
Abstract: We report a rare case of acute myeloid leukemia (AML) with a cytogenetically complex karyotype with coexistence of KMT2A/MLL Mixed Lineage Leukemia (11q23) rearrangement with 5q deletion and 7q deletion as unrelated clones along with… read more here.
Keywords: deletion; myeloid leukemia; complex karyotype; acute myeloid ... See more keywords