Prognostic Significance of Complex Karyotypes in Acute Myeloid Leukemia
Sign Up to like & getrecommendations! Published in 2019 at "Current Treatment Options in Oncology"
DOI: 10.1007/s11864-019-0612-y
Abstract: Opinion statementAcute myeloid leukemia (AML) patients with a complex karyotype (CK-AML) show at least 3 unrelated clonal cytogenetic abnormalities with notoriously poor outcome. Such cases fall into either AML with myelodysplasia-related changes or therapy-related AML… read more here.
Keywords: complex karyotypes; significance complex; aml patients; myeloid leukemia ... See more keywords
Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes that Are Eliminated by the Immune System.
Sign Up to like & getrecommendations! Published in 2017 at "Developmental cell"
DOI: 10.1016/j.devcel.2017.05.022
Abstract: Aneuploidy, a state of karyotype imbalance, is a hallmark of cancer. Changes in chromosome copy number have been proposed to drive disease by modulating the dosage of cancer driver genes and by promoting cancer genome… read more here.
Keywords: complex karyotypes; mis segregation; cell cycle; chromosome mis ... See more keywords
Study of the Chromosomal Abnormalities and Associated Complex Karyotypes in Hematological Cancer in the Population of West Bengal: A Prospective Observational Study
Sign Up to like & getrecommendations! Published in 2021 at "Indian Journal of Medical and Paediatric Oncology"
DOI: 10.1055/s-0041-1733827
Abstract: Introduction Chromosomal instability is an important feature of hematological cancer. The pathogenesis is complex and it involves genetic and epigenetic factors. As a genetic factor, chromosomal instability may play a key role in leukemogenesis. Accumulation… read more here.
Keywords: complex karyotypes; study; chromosomal instability; hematological cancer ... See more keywords
High karyotypic complexity is an independent prognostic factor in patients with CLL treated with venetoclax combinations.
Sign Up to like & getrecommendations! Published in 2023 at "Blood"
DOI: 10.1182/blood.2023019634
Abstract: Complex karyotypes have been associated with inferior outcomes in chronic lymphocytic leukemia (CLL) treated with chemoimmunotherapy (CIT) while their prognostic impact in the context of venetoclax-based treatments is still debated. In this prospective analysis on… read more here.
Keywords: cll treated; venetoclax based; complexity; complex karyotypes ... See more keywords