Patent Cliffs in the Era of Complex Therapies and Biologics
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutical Medicine"
DOI: 10.1007/s40290-020-00348-7
Abstract: The rise of new product classes such as biologics and complex molecules over the past two decades have brought to light some of the unique market dynamics that such products face. While we have seen… read more here.
Keywords: complex molecules; product; product classes; biologics complex ... See more keywords
A Rigorous Method for Identifying a One-Dimensional Reaction Coordinate in Complex Molecules.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical theory and computation"
DOI: 10.1021/acs.jctc.2c00132
Abstract: Understanding the mechanism of functional protein dynamics is critical to understanding protein functions. Reaction coordinate (RC) is a central topic in protein dynamics, and the grail is to find the one-dimensional RC (1D-RC) that can… read more here.
Keywords: method; complex molecules; reaction coordinate; reaction ... See more keywords
Coulomb Explosion Imaging of Complex Molecules Using Highly Charged Ions.
Sign Up to like & getrecommendations! Published in 2024 at "Physical review letters"
DOI: 10.1103/physrevlett.133.193002
Abstract: Rapidly stripping off multiple electrons from the target and triggering complete fragmentation with each constituent atom being charged up are ideal prerequisites for Coulomb explosion imaging. Here, we demonstrate that highly charged ion beam with… read more here.
Keywords: complex molecules; coulomb explosion; explosion; explosion imaging ... See more keywords
Vibrational nonlinear response of complex molecules: theory and measurements in the THz range.
Sign Up to like & getrecommendations! Published in 2025 at "Optics letters"
DOI: 10.1364/ol.566076
Abstract: The nonlinear optical response of materials under high-intensity electromagnetic fields is key to advancing THz optical technologies. This study introduces a theoretical approach to estimate the nonlinear refractive index coefficient, , of complex molecules in… read more here.
Keywords: complex molecules; optics; vibrational nonlinear; thz range ... See more keywords