A hydride transfer complex reprograms NAD metabolism and bypasses senescence.
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DOI: 10.1016/j.molcel.2021.08.028
Abstract: Metabolic rewiring and redox balance play pivotal roles in cancer. Cellular senescence is a barrier for tumorigenesis circumvented in cancer cells by poorly understood mechanisms. We report a multi-enzymatic complex that reprograms NAD metabolism by… read more here.
Keywords: nad metabolism; complex reprograms; senescence; hydride transfer ... See more keywords