A complex suite of loci and elements in eukaryotic type II topoisomerases determine selective sensitivity to distinct poisoning agents
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DOI: 10.1093/nar/gkz579
Abstract: Abstract Type II topoisomerases catalyze essential DNA transactions and are proven drug targets. Drug discrimination by prokaryotic and eukaryotic topoisomerases is vital to therapeutic utility, but is poorly understood. We developed a next-generation sequencing (NGS)… read more here.
Keywords: type topoisomerases; drug; sensitivity; complex suite ... See more keywords