Investigating the prediction of CpG methylation levels from SNP genotype data to help elucidate relationships between methylation, gene expression and complex traits
Sign Up to like & getrecommendations! Published in 2022 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22496
Abstract: As popularised by PrediXcan (and related methods), transcriptome‐wide association studies (TWAS), in which gene expression is imputed from single‐nucleotide polymorphism (SNP) genotypes and tested for association with a phenotype, are a popular approach for investigating… read more here.
Keywords: cpg methylation; methylation; gene expression; complex traits ... See more keywords
Genetic Bases of Complex Traits: From Quantitative Trait Loci to Prediction.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-2205-6_1
Abstract: Conceived as a general introduction to the book, this chapter is a reminder of the core concepts of genetic mapping and molecular marker-based prediction. It provides an overview of the principles and the evolution of… read more here.
Keywords: bases complex; genetic bases; marker; prediction ... See more keywords
Genomic Prediction of Complex Traits in Perennial Plants: A Case for Forest Trees.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-2205-6_18
Abstract: This chapter provides an overview of the genomic selection progress in long-lived forest tree species. Factors affecting the prediction accuracy in genomic prediction are assessed with examples from empirical studies. Infrastructure and resources required for… read more here.
Keywords: genomic prediction; prediction complex; traits perennial; prediction ... See more keywords
Advances in genome-wide association studies of complex traits in rice
Sign Up to like & getrecommendations! Published in 2019 at "Theoretical and Applied Genetics"
DOI: 10.1007/s00122-019-03473-3
Abstract: Genome-wide association studies (GWAS), genetic surveys of the whole genome to detect variants associated with a trait in natural populations, are a powerful approach for dissecting complex traits. This genetic mapping approach has been applied… read more here.
Keywords: genome wide; association studies; rice; complex traits ... See more keywords
Evolutionary dynamics of complex traits in sexual populations in a heterogeneous environment: how normal?
Sign Up to like & getrecommendations! Published in 2022 at "Journal of mathematical biology"
DOI: 10.1007/s00285-021-01712-0
Abstract: When studying the dynamics of trait distribution of populations in a heterogeneous environment, classical models from quantitative genetics choose to look at its system of moments, specifically the first two ones. Additionally, in order to… read more here.
Keywords: heterogeneous environment; https doi; evolutionary dynamics; doi org ... See more keywords
The road less traveled: from genotype to phenotype in flies and humans
Sign Up to like & getrecommendations! Published in 2017 at "Mammalian Genome"
DOI: 10.1007/s00335-017-9722-7
Abstract: Understanding how genomic variation gives rise to phenotypic variation is essential for elucidating mechanisms of adaptive evolution, plant and animal breeding, and precision medicine. However, identifying causal links between DNA sequence variants and variation in… read more here.
Keywords: human populations; variation; less traveled; genetic architectures ... See more keywords
Simulated nonlinear genetic and environmental dynamics of complex traits
Sign Up to like & getrecommendations! Published in 2022 at "Development and psychopathology"
DOI: 10.1017/s0954579421001796
Abstract: Genetic studies of complex traits often show disparities in estimated heritability depending on the method used, whether by genomic associations or twin and family studies. We present a simulation of individual genomes with dynamic environmental… read more here.
Keywords: complex traits; simulated nonlinear; gene environment; nonlinear genetic ... See more keywords
Dissecting the genetics of complex traits using summary association statistics
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Genetics"
DOI: 10.1038/nrg.2016.142
Abstract: During the past decade, genome-wide association studies (GWAS) have been used to successfully identify tens of thousands of genetic variants associated with complex traits and diseases. These studies have produced extensive repositories of genetic variation… read more here.
Keywords: association statistics; genetics; summary association; association ... See more keywords
Multi-omics study for interpretation of genome-wide association study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Human Genetics"
DOI: 10.1038/s10038-020-00842-5
Abstract: Genome-wide association studies (GWASs) have identified thousands of genetic loci associated with complex traits, including a wide variety of diseases. Despite the successful identification of associated loci, interpreting GWAS findings remains challenging and requires other… read more here.
Keywords: genome wide; multi omics; omics data; complex traits ... See more keywords
Global genetic differentiation of complex traits shaped by natural selection in humans
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-04191-y
Abstract: There are mean differences in complex traits among global human populations. We hypothesize that part of the phenotypic differentiation is due to natural selection. To address this hypothesis, we assess the differentiation in allele frequencies… read more here.
Keywords: genetic differentiation; differentiation; complex traits; differentiation complex ... See more keywords
Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07070-8
Abstract: The role of rare variants in complex traits remains uncharted. Here, we conduct deep whole genome sequencing of 1457 individuals from an isolated population, and test for rare variant burdens across six cardiometabolic traits. We… read more here.
Keywords: deep whole; whole genome; variant; complex traits ... See more keywords