The hydroxypropyl–β-cyclodextrin complexation of toltrazuril for enhancing bioavailability
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DOI: 10.2147/dddt.s157611
Abstract: Introduction Toltrazuril (Tol) is used to prevent and combat coccidiosis. However, its low aqueous solubility and poor oral bioavailability limit clinical application. Methods To overcome the shortcomings, toltrazuril–hydroxypropyl–β-cyclodextrin inclusion complex (Tol-HP-β-CD) was prepared and characterized.… read more here.
Keywords: complexation toltrazuril; bioavailability; hydroxypropyl cyclodextrin; tol ... See more keywords