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Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13503
Abstract: Characterizing interactions of Synaptotagmin‐1 with the SNARE complex is crucial to understand the mechanism of neurotransmitter release. X‐ray crystallography revealed how the Synaptotagmin‐1 C2B domain binds to the SNARE complex through a so‐called primary interface…
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Keywords:
snare;
tripartite interface;
complexin;
synaptotagmin snare ... See more keywords
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Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2138
Abstract: Single vesicle-vesicle fusion assays based on FRET of lipid or content mixing [1-3] are widely used to investigate complexin on vesicle docking [4] and fast fusion process [5]. Most recently, we discovered the important role…
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Keywords:
synaptic vesicles;
diao;
complexin;
membrane defects ... See more keywords
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Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107926
Abstract: Summary The neuronal protein complexin contains multiple domains that exert clamping and facilitatory functions to tune spontaneous and action potential-triggered synaptic release. We address the clamping mechanism and show that the accessory helix of complexin…
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Keywords:
membrane proximal;
complexin;
accessory helix;
membrane ... See more keywords
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Published in 2017 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2017.00154
Abstract: Complexin is a small soluble presynaptic protein that interacts with neuronal SNARE proteins in order to regulate synaptic vesicle exocytosis. While the SNARE-binding central helix of complexin is required for both the inhibition of spontaneous…
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Keywords:
inhibitory function;
terminal domain;
membrane bound;
complexin ... See more keywords
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Published in 2018 at "eLife"
DOI: 10.7554/elife.36497
Abstract: SNARE complex disassembly by the ATPase NSF is essential for neurotransmitter release and other membrane trafficking processes. We developed a single-molecule FRET assay to monitor repeated rounds of NSF-mediated disassembly and reassembly of individual SNARE…
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Keywords:
snare;
nsf mediated;
snare complex;
complexin ... See more keywords
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1
Published in 2022 at "eLife"
DOI: 10.7554/elife.71938
Abstract: Previously we reported that Synaptotagmin-1 and Complexin synergistically clamp the SNARE assembly process to generate and maintain a pool of docked vesicles that fuse rapidly and synchronously upon Ca2+ influx (Ramakrishnan et al., 2020). Here,…
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Keywords:
activation;
molecular determinants;
determinants complexin;
fusion ... See more keywords