Insights from analyses of low complexity regions with canonical methods for protein sequence comparison
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbac299
Abstract: Abstract Low complexity regions are fragments of protein sequences composed of only a few types of amino acids. These regions frequently occur in proteins and can play an important role in their functions. However, scientists… read more here.
Keywords: similarity; low complexity; comparison; complexity regions ... See more keywords
High-complexity regions in mammalian genomes are enriched for developmental genes
Sign Up to like & getrecommendations! Published in 2019 at "Bioinformatics"
DOI: 10.1093/bioinformatics/bty922
Abstract: Abstract Motivation Unique sequence regions are associated with genetic function in vertebrate genomes. However, measuring uniqueness, or absence of long repeats, along a genome is conceptually and computationally difficult. Here we use a variant of… read more here.
Keywords: mammalian genomes; high complexity; complexity; complexity regions ... See more keywords
Purine-rich low complexity regions are potential RNA binding hubs in the human genome
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DOI: 10.12688/f1000research.13522.2
Abstract: Many long noncoding RNAs are bound to the chromatin and some of these interactions are mediated by triple helices. It is usually assumed that a transcript can form triplexes with a distinct set of genomic… read more here.
Keywords: rich low; human genome; universal ttss; low complexity ... See more keywords
The Conservation of Low Complexity Regions in Bacterial Proteins Depends on the Pathogenicity of the Strain and Subcellular Location of the Protein
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DOI: 10.3390/genes12030451
Abstract: Low complexity regions (LCRs) in proteins are characterized by amino acid frequencies that differ from the average. These regions evolve faster and tend to be less conserved between homologs than globular domains. They are not… read more here.
Keywords: complexity regions; low complexity; subcellular location; conservation ... See more keywords