Nationwide observational study of mortality from complicated intra‐abdominal infections and the role of bacterial cultures
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DOI: 10.1002/bjs.11095
Abstract: The benefit of taking intra‐abdominal cultures during source control procedures in patients with complicated intra‐abdominal infection (CIAI) is unknown. The aim of this study was to evaluate whether intra‐abdominal cultures reduce the mortality rate of… read more here.
Keywords: observational study; nationwide observational; mortality; intra abdominal ... See more keywords
Epidemiology and Risk Factors for Isolation of Multi-Drug-Resistant Organisms in Patients with Complicated Intra-Abdominal Infections.
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DOI: 10.1089/sur.2017.217
Abstract: BACKGROUND Patients with complicated intra-abdominal infections (cIAIs) caused by multi-drug-resistant organisms (MDROs) have been identified as being at increased risk for adverse outcomes. Prompt identification and stratification of these patients is essential in the clinical… read more here.
Keywords: risk; patients complicated; risk factors; epidemiology ... See more keywords
Clinical Practice Guidelines in Complicated Intra-Abdominal Infection 2018: An Indonesian Perspective.
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DOI: 10.1089/sur.2018.120
Abstract: BACKGROUND The occurrence of complicated intra-abdominal infections (cIAI) remains high despite system improvement in accordance with Joint Commission International because of heterogeneity of management. However, published clinical practice guidelines (CPGs) were not feasible to be… read more here.
Keywords: clinical practice; cpgs; intra abdominal; abdominal infection ... See more keywords
Pharmacokinetics and safety of aztreonam/avibactam for the treatment of complicated intra-abdominal infections in hospitalized adults: results from the REJUVENATE study
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkz497
Abstract: Abstract Objectives To investigate pharmacokinetics (PK) and safety (primary objectives) and efficacy (secondary objective) of the investigational monobactam/β-lactamase inhibitor combination aztreonam/avibactam in patients with complicated intra-abdominal infection (cIAI). Methods This Phase 2a open-label, multicentre study… read more here.
Keywords: safety; aztreonam avibactam; min; pharmacokinetics safety ... See more keywords
Carbapenems vs tigecycline for the treatment of complicated intra-abdominal infections
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DOI: 10.1097/md.0000000000017436
Abstract: Supplemental Digital Content is available in the text read more here.
Keywords: tigecycline treatment; complicated intra; carbapenems tigecycline; abdominal infections ... See more keywords
Measuring outcomes in complicated intra-abdominal infections.
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DOI: 10.1097/mog.0000000000000591
Abstract: PURPOSE OF REVIEW Complicated intra-abdominal infections (cIAIs) are associated with significant morbidity and mortality. Clinical trials should help guide and improve the management of cIAIs. However, inappropriate selection or measurement of outcomes in cIAIs clinical… read more here.
Keywords: measuring outcomes; gastroenterology; outcomes complicated; complicated intra ... See more keywords
Untargeted antifungal therapy in adult patients with complicated intra‐abdominal infection: a systematic review
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DOI: 10.1111/aas.13031
Abstract: Systematic reviews comparing untargeted antifungal treatment with placebo or no treatment in critically ill patients have provided conflicting results. We aimed to assess patient‐important benefits and harms of untargeted antifungal therapy vs. placebo or no… read more here.
Keywords: antifungal therapy; patients complicated; untargeted antifungal; adult patients ... See more keywords
Dose Selection and Validation for Ceftazidime-Avibactam in Adults with Complicated Intra-abdominal Infections, Complicated Urinary Tract Infections, and Nosocomial Pneumonia
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DOI: 10.1128/aac.02187-18
Abstract: Avibactam is a non-β-lactam β-lactamase inhibitor that has been approved in combination with ceftazidime for the treatment of complicated intra-abdominal infections, complicated urinary tract infections, and nosocomial pneumonia, including ventilator-associated pneumonia. In Europe, ceftazidime-avibactam is… read more here.
Keywords: treatment; complicated intra; ceftazidime; ceftazidime avibactam ... See more keywords
Eravacycline: a new treatment option for complicated intra-abdominal infections in the age of multidrug resistance.
Sign Up to like & getrecommendations! Published in 2019 at "Future microbiology"
DOI: 10.2217/fmb-2019-0135
Abstract: Aim: Recently approved for use in complicated intra-abdominal infection, eravacycline is a novel fluorocycline with broad spectrum of activity against resistant Gram-negative pathogens. This manuscript is a pooled analysis of two Phase III trials. Clinical… read more here.
Keywords: option; treatment; eravacycline versus; abdominal infections ... See more keywords
Ceftolozane/Tazobactam In-Vitro Activity against Clinical Isolates from Complicated Intra-Abdominal Infection Patients in Three Indonesian Referral Hospitals
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DOI: 10.3390/antibiotics12010052
Abstract: Complicated intra-abdominal infections (cIAIs) lead to high morbidity and mortality, especially if poorly managed. However, Indonesia’s microbial pattern and susceptibility data are limited, especially for new antibiotics. Ceftolozane/tazobactam (C/T) is reported to be a new… read more here.
Keywords: ceftolozane tazobactam; clinical isolates; vitro activity; activity clinical ... See more keywords
Ceftazidime-avibactam plus metronidazole vs. meropenem in complicated intra-abdominal infections: Indian subset from RECLAIM.
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DOI: 10.3855/jidc.14912
Abstract: INTRODUCTION This study analyzes the safety and efficacy results of the Indian population subset from the RECLAIM trial investigating the non-inferiority of Ceftazidime-Avibactam (CAZ-AVI) plus metronidazole to meropenem and interprets its relevance. METHODOLOGY The study… read more here.
Keywords: meropenem; ceftazidime avibactam; complicated intra; metronidazole meropenem ... See more keywords