Physiologically‐Based Pharmacokinetic model for Ciprofloxacin in children with complicated Urinary Tract Infection
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2018.11.033
Abstract: &NA; In a recent multicenter population pharmacokinetic study of ciprofloxacin administered to children suffering from complicated urinary tract infection (cUTI), the apparent volume of distribution (V) and total plasma clearance (CL) were decreased by 83.6%… read more here.
Keywords: urinary tract; complicated urinary; physiologically based; ciprofloxacin ... See more keywords
Evaluating imipenem + cilastatin + relebactam for the treatment of complicated urinary tract infections
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2020.1790525
Abstract: ABSTRACT Introduction The addition of the β-lactamase inhibitor relebactam to imipenem restores the antibacterial activity against the majority of multidrug resistant Gram-negative bacteria. Complicated urinary tract infections (UTIs) are predominantly caused by Gram-negative uropathogens. The… read more here.
Keywords: imipenem; relebactam; urinary tract; complicated urinary ... See more keywords
Plazomicin: an intravenous aminoglycoside antibacterial for the treatment of complicated urinary tract infections
Sign Up to like & getrecommendations! Published in 2020 at "Expert Review of Anti-infective Therapy"
DOI: 10.1080/14787210.2020.1759419
Abstract: ABSTRACT Introduction Antimicrobial resistance continues to be a major public health concern due to the emergence and spread of multi-drug resistant (MDR) organisms, including extended spectrum ß-lactamase (ESBL) and carbapenemase producing Enterobacterales. Plazomicin is a… read more here.
Keywords: urinary tract; complicated urinary; tract infections; plazomicin ... See more keywords
Vancomycin-arginine (STM-001) abrogates ESBL carrier and carbapenem-resistant Escherichia coli burden in a murine complicated urinary tract infection model
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkac063
Abstract: Abstract Objectives STM-001, a retargeted glycopeptide, is active against MDR E. coli expressing ESBLs including carbapenemases. Herein, we assessed its capability to combat E. coli complicated urinary tract infections (cUTI) in mice driven by clinically… read more here.
Keywords: urinary tract; stm 001; complicated urinary; burden ... See more keywords
1673. Epidemiology of Complicated Urinary Tract Infections (cUTIs) Presenting in Emergency Departments Across the United States (US)
Sign Up to like & getrecommendations! Published in 2020 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofaa439.1851
Abstract: Complicated urinary tract infection (cUTI) is a common emergency department (ED) diagnosis. Results of urine culture and antimicrobial susceptibility testing are usually not available for up to 48 hours after an ED visit; therefore, diagnosis… read more here.
Keywords: urinary tract; complicated urinary; emergency; epidemiology ... See more keywords
Intravenous Fosfomycin (ZTI-01) for the Treatment of Complicated Urinary Tract Infections (cUTI) Including Acute Pyelonephritis (AP): Results from a Multi-center, Randomized, Double-Blind Phase 2/3 Study in Hospitalized Adults (ZEUS)
Sign Up to like & getrecommendations! Published in 2017 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofx163.1375
Abstract: Keith S. Kaye, MD, MPH1, Louis B. Rice, MD, FIDSA2, Aaron Dane, PhD3, Viktor Stus, MD, PhD4, Olexsiy Sagan, MD5, Elena Fedosiuk, MD6, Anita Das, PhD7, David Skarinsky, BS8, Paul B Eckburg, MD8 and Evelyn… read more here.
Keywords: urinary tract; intravenous fosfomycin; complicated urinary; fosfomycin zti ... See more keywords
Carbapenems vs alternative antibiotics for the treatment of complicated urinary tract infection
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DOI: 10.1097/md.0000000000018769
Abstract: Supplemental Digital Content is available in the text read more here.
Keywords: antibiotics treatment; carbapenems alternative; complicated urinary; alternative antibiotics ... See more keywords
Multiple antimicrobial resistance and outcomes among hospitalized patients with complicated urinary tract infections in the US, 2013–2018: a retrospective cohort study
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DOI: 10.1186/s12879-021-05842-0
Abstract: Background Complicated urinary tract infection (cUTI) is common among hospitalized patients. Though carbapenems are an effective treatment in the face of rising resistance, overuse drives carbapenem resistance (CR). We hypothesized that resistance to routinely used… read more here.
Keywords: among hospitalized; urinary tract; complicated urinary; retrospective cohort ... See more keywords
Cefiderocol to treat complicated urinary tract infection.
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DOI: 10.1358/dot.2020.56.3.3118466
Abstract: On November 14, 2019, the U.S. Food and Drug Administration (FDA) approved cefiderocol, a siderophore-cephalosporin conjugate antibiotic, for the treatment of adults with complicated urinary tract infections (cUTIs), including kidney infections caused by susceptible Gram-negative… read more here.
Keywords: urinary tract; cefiderocol treat; complicated urinary; tract infection ... See more keywords
Unmet Needs in Complicated Urinary Tract Infections: Challenges, Recommendations, and Emerging Treatment Pathways
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DOI: 10.2147/idr.s382617
Abstract: Abstract While urinary tract infections (UTIs) are one of the most common types of infections globally, the wide variety of presentations and of severity of disease can make it difficult to manage. The definition for… read more here.
Keywords: urinary tract; tract infections; complicated urinary; unmet needs ... See more keywords
Trends of antimicrobial resistance in patients with complicated urinary tract infection: Suggested empirical therapy and lessons learned from a retrospective observational study in Oman
Sign Up to like & getrecommendations! Published in 2022 at "Urology Annals"
DOI: 10.4103/ua.ua_67_22
Abstract: Background: Complicated urinary tract infection (cUTI) is defined as an infection associated with structural, functional, or metabolic abnormalities of the genitourinary tract. These infections are caused frequently by multidrug-resistant Gram-negative bacilli. The rapid emergence of… read more here.
Keywords: urinary tract; infection; resistance; complicated urinary ... See more keywords