Identification of Binding Sites for Efflux Pump Inhibitors of the AcrAB-TolC Component AcrA.
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DOI: 10.1016/j.bpj.2019.01.010
Abstract: The overexpression of multidrug efflux pumps is an important mechanism of clinical resistance in Gram-negative bacteria. Recently, four small molecules were discovered that inhibit efflux in Escherichia coli and interact with the AcrAB-TolC efflux pump… read more here.
Keywords: component acra; binding sites; acrab tolc; efflux pump ... See more keywords