Mechanistic details of amino acid catalyzed two-component Mannich reaction: experimental study backed by density functional calculations
Sign Up to like & getrecommendations! Published in 2019 at "Amino Acids"
DOI: 10.1007/s00726-019-02798-z
Abstract: The role of pH-dependent ionic structures of l-amino acids in catalysis has been investigated for the two-component Mannich reactions between dimethyl malonate (DMM)/ethyl acetoacetate (EAA) and imines. As catalysts, l-amino acids performed well, even better… read more here.
Keywords: density functional; amino acids; amino acid; functional calculations ... See more keywords
Synthesis of β-fluoro(dicarbonyl)ethylamines from 2-fluoro-ethylacetoacetate and dimethyl-2-fluoromalonate ester by batch and semi-continuous flow three-component Mannich reactions
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Fluorine Chemistry"
DOI: 10.1016/j.jfluchem.2017.12.012
Abstract: Abstract Multi-component Mannich reactions between 2-fluoro-ethylacetoacetate or dimethyl-2-fluoromalonate ester, aldehyde and amine components allowing convenient synthesis of β-fluoro(dicarbonyl)ethylamine systems using both batch and continuous flow techniques are reported. read more here.
Keywords: ethylacetoacetate dimethyl; dimethyl fluoromalonate; fluoromalonate ester; component mannich ... See more keywords