Four-Component Reaction for the Synthesis of Indolizines by Copper-Catalyzed Aerobic Oxidative Dehydrogenative Aromatization
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DOI: 10.1002/ejoc.201601272
Abstract: A one-pot, four-component reaction was developed for the synthesis of indolizines from pyridines, α-halide carbonyl compounds, primary amines, and maleic anhydride. The key step in this reaction involved the copper-catalyzed aerobic oxidative aromatization of a… read more here.
Keywords: four component; reaction; synthesis indolizines; component reaction ... See more keywords
Conditional symmetries and exact solutions of a nonlinear three-component reaction-diffusion model
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DOI: 10.1017/s0956792520000121
Abstract: Abstract Q-conditional (non-classical) symmetries of the known three-component reaction-diffusion (RD) system [K. Aoki et al. Theor. Popul. Biol. 50, 1–17 (1996)] modelling interaction between farmers and hunter-gatherers are constructed for the first time. A wide… read more here.
Keywords: reaction diffusion; three component; component reaction; conditional symmetries ... See more keywords
Synthesis of Thiazoles and Isothiazoles via Three-Component Reaction of Enaminoesters, Sulfur, and Bromodifluoroacetamides/Esters.
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DOI: 10.1021/acs.orglett.0c01275
Abstract: A three-component strategy for the synthesis of thiazoles and isothiazoles has been developed by employing enaminoesters, fluorodibromoiamides/ester, and sulfur. The thiazoles and isothiazoles were formed via two C-F bond cleavages along with the formation of… read more here.
Keywords: synthesis thiazoles; thiazoles isothiazoles; via three; isothiazoles via ... See more keywords
Copper-Catalyzed 1,1-Boroalkylation of Terminal Alkynes: Access to Alkenylboronates via a Three-Component Reaction.
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DOI: 10.1021/acs.orglett.1c01081
Abstract: A copper-catalyzed three-component reaction of terminal alkynes, diazo compounds, and B2pin2 to prepare trisubstituted alkenylboronates has been developed. This difunctionalization of alkynes selectively occurs at the terminal carbon atom and proceeds via a tandem sequence.… read more here.
Keywords: copper; terminal alkynes; three component; component reaction ... See more keywords
Copper-Mediated Three-Component Reaction for the Synthesis of N-Acylsulfonamide on DNA.
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DOI: 10.1021/acs.orglett.2c01675
Abstract: The DNA-encoded library (DEL) technology is a new method for discovering hit compounds for target proteins in the pharmaceutical industry. The N-acylsulfonamide functional group has been reported to exhibit various pharmacological activities, and based on… read more here.
Keywords: copper; dna; mediated three; copper mediated ... See more keywords
Photocatalytic Defluorinative Three-Component Reaction of α-Trifluoromethyl Alkenes, Alkenes, and Sodium Sulfinates: Synthesis of Monofluorocyclopentenes.
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DOI: 10.1021/acs.orglett.2c02202
Abstract: A photocatalytic three-component reaction of α-trifluoromethyl alkenes, electron-rich alkenes, and sodium sulfinates for the synthesis of gem-difluoroalkenes in a radical/polar crossover manner was developed. Due to the strong electron-withdrawing nature of the sulfonyl group, the… read more here.
Keywords: trifluoromethyl alkenes; sodium sulfinates; component reaction; three component ... See more keywords
Rhodium-Catalyzed Three-Component Reaction of Alkynes, Arylzinc Chlorides, and Iodomethanes Producing Trisubstituted/Tetrasubstituted Alkenes with/without 1,4-Migration.
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DOI: 10.1021/acs.orglett.2c02299
Abstract: A three-component reaction of alkynes, arylzinc chlorides, and iodomethanes was found to proceed in the presence of a rhodium catalyst to give high yields of trisubstituted/tetrasubstituted alkenes. The usual arylzinc chlorides only gave trisubstituted alkenes,… read more here.
Keywords: arylzinc chlorides; reaction alkynes; component reaction; migration ... See more keywords
Isocyanide Heterodimerization-Triggered Three-Component Reaction: Diversity-Oriented Synthesis of Quinoxalines.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00794
Abstract: Known isocyanide-based multicomponent reactions (IMCRs) are usually triggered by addition of the isocyano group to the strong electrophilic component. We herein report a new isocyanide-based three-component reaction, in which an unprecedented quinoxaline-based zwitterionic intermediate is… read more here.
Keywords: component reaction; three component; isocyanide heterodimerization;
Regioselective Three-Component Reaction of Pyridine N-Oxides, Acyl Chlorides, and Cyclic Ethers.
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DOI: 10.1021/acs.orglett.7b01481
Abstract: A novel three-component reaction of pyridine N-oxides, acyl chlorides, and cyclic ethers is described. Treatment of an electron-deficient pyridine N-oxide with an acyl chloride in the presence of a cyclic ether at 25-50 °C leads… read more here.
Keywords: pyridine; reaction pyridine; pyridine oxides; three component ... See more keywords
Controllable Stereoselective Synthesis of (Z)- and (E)-Homoallylic Alcohols Using a Palladium-Catalyzed Three-Component Reaction.
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DOI: 10.1021/acs.orglett.7b02979
Abstract: Diastereoselective synthesis of (Z)- and (E)-homoallylic alcohols using a Pd-catalyzed three-component reaction of 3-(pinacolatoboryl)allyl benzoates, aldehydes, and aryl stannanes was developed, which provides an alternative method for the allylboration of aldehydes using α,γ-diaryl-substituted allylboronates. Both… read more here.
Keywords: synthesis homoallylic; catalyzed three; homoallylic alcohols; three component ... See more keywords
Cu(I)-Catalyzed Three-Component Reaction of Diazo Compound with Terminal Alkyne and Nitrosobenzene for the Synthesis of Trifluoromethyl Dihydroisoxazoles.
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DOI: 10.1021/acs.orglett.8b01981
Abstract: A Cu(I)-catalyzed three-component reaction of terminal alkynes, trifluoromethyl diazo compounds, and nitrosoarenes was developed. With this method, a series of trifluoromethyl-substituted dihydroisoxazoles were effectively synthesized in high yields under mild reaction conditions. This transformation is… read more here.
Keywords: catalyzed three; three component; reaction; trifluoromethyl ... See more keywords