Microwave-assisted Three-component Reactions for Regioselective Synthesis of Functionalized Benzo[e]indoles
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.2962
Abstract: Microwave-assisted three-component reactions of arylglyoxals with cyclic 1,3-dicarbonyl compounds and naphthalen-2-amine have been established, by which a series of new functionalized benzo[e]indoles with good yields were synthesized. The reaction was easily conducted in HOAc, enabling… read more here.
Keywords: assisted three; microwave assisted; three component; benzo indoles ... See more keywords
Synthesis of 1,6-diamino-2-imino-2,3-dihydropyrimidin-4(1Н)-one and preliminary study of its two- and three-component reactions
Sign Up to like & getrecommendations! Published in 2017 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-017-2078-9
Abstract: A new heterocyclic compound, 1,6-diamino-2-imino-2,3-dihydropyrimidin-4(1H)-one, was synthesized for the first time and some of its chemical properties were studied. This pyrimidinone showed very unusual reactivity comparing to analogous compounds in reactions with alkylating and acylating… read more here.
Keywords: diamino imino; component reactions; imino dihydropyrimidin; dihydropyrimidin one ... See more keywords
Transport Effects on Multiple-Component Reactions in Optical Biosensors
Sign Up to like & getrecommendations! Published in 2017 at "Bulletin of Mathematical Biology"
DOI: 10.1007/s11538-017-0327-9
Abstract: Optical biosensors are often used to measure kinetic rate constants associated with chemical reactions. Such instruments operate in the surface–volume configuration, in which ligand molecules are convected through a fluid-filled volume over a surface to… read more here.
Keywords: transport effects; reactions optical; optical biosensors; multiple component ... See more keywords
Highly Reactive Palladium-Catalyzed and Acetonitrile-Mediated Three-Component Reactions for Arylsulfone Synthesis.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03430
Abstract: Arylsulfone groups play an important role in the synthesis of functionalized molecules. The acetonitrile-mediated three-component reactions for arylsulfone synthesis were developed in the presence of a 0.00025 mol % palladium catalyst. Arylboronic acids reacted with… read more here.
Keywords: component reactions; reactions arylsulfone; mediated three; synthesis ... See more keywords
Regio- and Diastereoselective Three-Component Reactions via Trapping of Ammonium Ylides with N-Alkylquinolinium Salts: Synthesis of Multisubstituted Tetra- and Dihydroquinoline Derivatives.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b01664
Abstract: Pd(II)-catalyzed three-component reactions via trapping of ammonium ylides with N-alkylquinolinium salts are reported. These reactions provided polyfunctional polycyclic tetrahydroquinolines or 4-substituted 1,4-dihydroquinolines in excellent yields (89-99% and 89-98%, respectively) with high regioselectivities and moderate to… read more here.
Keywords: component reactions; reactions via; ammonium ylides; trapping ammonium ... See more keywords
Three-Component Reactions to Spirocyclic Pyrrolidinonylformimidamides: α-Isocyano Lactams as Two-Atom Unit in Silver-Catalyzed Formal [3 + 2] Cycloaddition Reactions.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b03118
Abstract: A facile approach to spirocyclic pyrrolidinonylformimidamides has been developed via three-component reactions of isocyanides, alkenes, and amines. The reaction proceeds through a sequence of two distinct reaction pathways; the base-catalyzed conjugate addition of α-isocyano lactams… read more here.
Keywords: cycloaddition; spirocyclic pyrrolidinonylformimidamides; atom unit; three component ... See more keywords
Facile synthesis of 1,4-diketones via three-component reactions of α-ketoaldehyde, 1,3-dicarbonyl compound, and a nucleophile in water
Sign Up to like & getrecommendations! Published in 2018 at "Green Chemistry"
DOI: 10.1039/c7gc03644b
Abstract: Three-component reactions of alkylglyoxals, 1,3-dicarbonyl compounds, and a nucleophile were performed under aqueous and catalyst-free conditions, which produced 1,4-diketone scaffolds in a straightforward way. Many compounds, such as indole, azaindole, pyrrole, 2-methylfuran, N,N-dimethylaniline, N-methylaniline, thiophenol,… read more here.
Keywords: diketones via; via three; facile synthesis; synthesis diketones ... See more keywords
Multi-Component Reactions of Cyclohexan-1,3-dione: Synthesis of Fused Pyran, Pyridine, Thiophene and Pyrazole Derivatives with c-Met, AntiProliferative Activities.
Sign Up to like & getrecommendations! Published in 2021 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520621666210112115128
Abstract: BACKGROUND Recently products of multi-component reactions (MCR's) acquired a special attention due to their wide range of pharmacological activities especially the therapeutic activities. Through the market it was found that many pharmacological drugs containing the… read more here.
Keywords: pyran pyridine; multi component; cyclohexan dione; cancer cell ... See more keywords
Recent Developments on Five-Component Reactions
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26071986
Abstract: Multicomponent reactions (MCRs) have inherent advantages in pot, atom, and step economy (PASE). This important green synthetic approach has gained increasing attention due to high efficiency, minimal waste, saving resources, and straightforward procedures. Presented in… read more here.
Keywords: developments five; component reactions; recent developments; five component ... See more keywords