On the substructure controls in rare variant analysis: Principal components or variance components?
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DOI: 10.1002/gepi.22102
Abstract: Recent studies showed that population substructure (PS) can have more complex impact on rare variant tests and that similarity‐based collapsing tests (e.g., SKAT) may suffer more severely by PS than burden‐based tests. In this work,… read more here.
Keywords: variance components; substructure; principal components; rare variant ... See more keywords