The combination of mitomycin-induced blood cells with a temporary treatment of ciclosporin A prolongs allograft survival in vascularized composite allotransplantation
Sign Up to like & getrecommendations! Published in 2017 at "Langenbeck's Archives of Surgery"
DOI: 10.1007/s00423-017-1616-3
Abstract: BackgroundVascularized composite allotransplantation (VCA) is a rapidly expanding field of transplantation and provides a potential treatment for complex tissue defects. Peripheral blood mononuclear cells (PBMCs) shortly incubated with the antibiotic and chemotherapeutic agent mitomycin C… read more here.
Keywords: combination; treatment; rejection; group ... See more keywords
A review of utilities and costs of treating upper extremity amputations with vascularized composite allotransplantation versus myoelectric prostheses in Canada
Sign Up to like & getrecommendations! Published in 2022 at "JPRAS Open"
DOI: 10.1016/j.jpra.2022.03.003
Abstract: Background Hand vascularized composite allotransplantation (VCA) and myoelectric prostheses have proven their efficacy for treating hand amputation. Despite reported functional outcomes, the lack of consensus on VCA versus myoelectric prostheses brought us to report on… read more here.
Keywords: vascularized composite; myoelectric prostheses; hand; versus myoelectric ... See more keywords
Prevention of Ischemia-Reperfusion Injury and Chronic Rejection in a Porcine Vascularized Composite Allotransplantation Model
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DOI: 10.1097/01.tp.0000543670.93080.cc
Abstract: Aim Modern body armor, rapid evacuation, and advanced combat casualty care have improved survival after catastrophic extremity and maxillofacial trauma. Restoration using vascularized composite allotransplantation (VCA) is superior to conventional reconstruction in such injuries but… read more here.
Keywords: allotransplantation; porcine; model; composite allotransplantation ... See more keywords
Genitourinary vascularized composite allotransplantation: a review of penile transplantation.
Sign Up to like & getrecommendations! Published in 2019 at "Current Opinion in Organ Transplantation"
DOI: 10.1097/mot.0000000000000704
Abstract: PURPOSE OF REVIEW Vascularized composite allotransplantation (VCA) has developed over the past 20 years, resulting in promising new reconstructive prospects for extensive soft tissue defects. More than 200 VCA's have been performed worldwide, including five… read more here.
Keywords: vascularized composite; review; vca; guvca ... See more keywords
Vascularized composite allotransplantation: emerging psychosocial issues in hand, face, and uterine transplant
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Organ Transplantation"
DOI: 10.1097/mot.0000000000001028
Abstract: Purpose of review Currently, several research approaches warrant further attention, given the influence of psychosocial and bioethical issues on the success of upper extremity (UETx), face (FTx), and uterine transplantation (UTx). This review will highlight… read more here.
Keywords: vascularized composite; emerging psychosocial; psychosocial issues; face ... See more keywords
Angiosome-Based Allografts: Vascularized Composite Allotransplantation for Tailored Subunit Reconstruction with Volkmann Ischemic Contracture as a Case in Point
Sign Up to like & getrecommendations! Published in 2017 at "Plastic and Reconstructive Surgery"
DOI: 10.1097/prs.0000000000003360
Abstract: Background: As we enter an age with new approaches to tissue reconstruction, the emphasis on the adage “like for like” has become even more relevant. This study illustrates the potential for several tailored vascularized composite… read more here.
Keywords: composite allotransplantation; volkmann ischemic; vascularized composite; contracture ... See more keywords
Reciprocal Donor-Recipient Strain Combinations Present Different Vascularized Composite Allotransplantation Outcomes in Rodent Models
Sign Up to like & getrecommendations! Published in 2022 at "Plastic and Reconstructive Surgery"
DOI: 10.1097/prs.0000000000010099
Abstract: Background: Although vascularized composite allotransplantation (VCA) has been the focus of many animal studies, further research is needed to determine the potential for a generalized model and immunosuppression regimen that applies across different donor-recipient combinations.… read more here.
Keywords: recipient; vascularized composite; recipient combinations; donor recipient ... See more keywords
Vascularized Composite Allotransplantation at a Crossroad: Adopting Lessons From Technology Innovation to Novel Clinical Applications.
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DOI: 10.1097/tp.0000000000001610
Abstract: T field of vascularized composite allotransplantation (VCA) is no longer in its infancy. More than 80 upper extremity transplants have been performed world-wide, in addition to 30 patients having received facial transplants. Other composite transplants… read more here.
Keywords: vca; field; allotransplantation crossroad; composite allotransplantation ... See more keywords
Cytomegalovirus-related Complications and Management in Facial Vascularized Composite Allotransplantation: An International Multicenter Retrospective Cohort Study
Sign Up to like & getrecommendations! Published in 2022 at "Transplantation"
DOI: 10.1097/tp.0000000000004132
Abstract: Background. There is a paucity of data on the impact of cytomegalovirus (CMV) serostatus and CMV infection on outcomes in facial vascularized composite allotransplantation. Methods. This international, multicenter, retrospective cohort study presents data on CMV… read more here.
Keywords: vascularized composite; international multicenter; related complications; facial vascularized ... See more keywords
Adipose‐derived stromal cell therapy combined with a short course nonmyeloablative conditioning promotes long‐term graft tolerance in vascularized composite allotransplantation
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Transplantation"
DOI: 10.1111/ajt.15726
Abstract: The risks of chronic immunosuppression limit the utility of vascularized composite allotransplantation (VCA) as a reconstructive option in complex tissue defects. We evaluated a novel, clinically translatable, radiation‐free conditioning protocol that combines anti‐lymphocyte serum (ALS),… read more here.
Keywords: term; long term; asc; composite allotransplantation ... See more keywords
In situ recruitment of regulatory T cells promotes donor-specific tolerance in vascularized composite allotransplantation
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aax8429
Abstract: CCL22-releasing microparticles recruit suppressive immune cells to transplanted rat limbs to promote long-term graft survival. Vascularized composite allotransplantation (VCA) encompasses face and limb transplantation, but as with organ transplantation, it requires lifelong regimens of immunosuppressive… read more here.
Keywords: tolerance; regulatory cells; composite allotransplantation; vascularized composite ... See more keywords