Interim monitoring in a treatment strategy trial with a composite primary endpoint.
Sign Up to like & getrecommendations! Published in 2019 at "Contemporary clinical trials"
DOI: 10.1016/j.cct.2019.105846
Abstract: When a clinical trial has a composite endpoint and a comparison of treatment strategies with multiple intervention components, interim data reviews by a data safety and monitoring board (DSMB) can be challenging as the data… read more here.
Keywords: trial; endpoint; treatment; study ... See more keywords
Impact of predictive value of Fibrosis-4 index in patients hospitalized for acute heart failure.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2020.09.056
Abstract: BACKGROUND Abnormalities in liver function tests commonly occur in patients with acute heart failure (AHF). The Fibrosis-4 (FIB4) index, a non-invasive and easily calculated marker, has been used for hepatic diseases and reflects adverse prognosis.… read more here.
Keywords: index; heart failure; index admission; acute heart ... See more keywords
The characteristics and predictive role of lymphocyte subsets in COVID-19 patients
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Infectious Diseases"
DOI: 10.1016/j.ijid.2020.06.079
Abstract: Abstract Objective To investigate the characteristics and predictive roles of lymphocyte subsets in COVID-19 patients. Method We evaluated lymphocyte subsets and other clinical features of COVID-19 patients and analysed their potential impacts on COVID-19 outcomes.… read more here.
Keywords: covid patients; characteristics predictive; lymphocyte subsets; subsets covid ... See more keywords
COPDCompEx: A novel composite endpoint for COPD exacerbations to enable faster clinical development.
Sign Up to like & getrecommendations! Published in 2020 at "Respiratory medicine"
DOI: 10.1016/j.rmed.2020.106175
Abstract: BACKGROUND Frequency of moderate and severe chronic obstructive pulmonary disease exacerbations is an important endpoint in clinical trials, but makes them large and lengthy when powered to evaluate it. We aimed to develop a composite… read more here.
Keywords: endpoint; copdcompex; treatment; event ... See more keywords
Interpretation of composite endpoints in urology: an analysis of citation quality
Sign Up to like & getrecommendations! Published in 2022 at "Scandinavian Journal of Urology"
DOI: 10.1080/21681805.2022.2058607
Abstract: Abstract Objective To investigate how urological studies using composite endpoints as the primary outcome were cited. Materials and methods In this quality analysis of citations, three randomized clinical trials each investigating oncological and non-oncological urology… read more here.
Keywords: quality; composite endpoints; citation; urology ... See more keywords
WHITE COAT EFFECT LEVEL CORRELATED WITH THE ECHOCARDIOGRAPHIC PARAMETERS AND COMPOSITE ENDPOINT DATA IN TREATED PATIENTS WITH ARTERIAL HYPERTENSION
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000836304.85633.cb
Abstract: Objective: The aim of our study was to determine relationship between echocardiography (Echo) left ventricular mass index (LVMI), composite endpoint data and white coat effect (WCE) level in treated patients with arterial hypertension (AH). Design… read more here.
Keywords: hypertension; endpoint; level; treated patients ... See more keywords
A Novel Immune Modulator for Patients With Necrotizing Soft Tissue Infections (NSTI)
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Surgery"
DOI: 10.1097/sla.0000000000004102
Abstract: Supplemental Digital Content is available in the text Background and Objective: Reltecimod, a CD 28 T-lymphocyte receptor mimetic, inhibits T-cell stimulation by an array of bacterial pathogens. A previous phase 2 trial demonstrated improved resolution… read more here.
Keywords: resolution; placebo; organ dysfunction; composite endpoint ... See more keywords
Validation of a clinical trial composite endpoint for patients with necrotizing soft tissue infections
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Trauma and Acute Care Surgery"
DOI: 10.1097/ta.0000000000001564
Abstract: OBJECTIVE Our objective was to develop and validate a composite endpoint for patients with necrotizing soft tissue infections that incorporates: local tissue injury, systemic organ dysfunction, and mortality. METHODS The Necrotizing Infection Clinical Composite Endpoint… read more here.
Keywords: necrotizing soft; endpoint; soft tissue; tissue ... See more keywords
Examining the construct and known-group validity of a composite endpoint for The Older Persons and Informal Caregivers Survey Minimum Data Set (TOPICS-MDS); A large-scale data sharing initiative
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0173081
Abstract: Background Preference-weighted multi-faceted endpoints have the potential to facilitate comparative effectiveness research that incorporates patient preferences. The Older Persons and Informal Caregivers Survey—Composite endpoint (TOPICS-CEP) is potentially a valuable outcome measure for evaluating interventions in… read more here.
Keywords: older persons; topics cep; caregivers survey; informal caregivers ... See more keywords
Bin-CE: A comprehensive web application to decide upon the best set of outcomes to be combined in a binary composite endpoint
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0209000
Abstract: The estimation of the Sample Size Requirement (SSR) when using a binary composite endpoint (i.e. two or more outcomes combined in a unique primary endpoint) is not trivial. Besides information about the rate of events… read more here.
Keywords: outcomes combined; endpoint; association outcomes; bin ... See more keywords
National Early Warning Score and New-Onset Atrial Fibrillation for Predicting In-Hospital Mortality or Transfer to the Intensive Care Unit in Emergency Department Patients with Suspected Bacterial Infections
Sign Up to like & getrecommendations! Published in 2022 at "Infection and Drug Resistance"
DOI: 10.2147/idr.s358544
Abstract: Purpose There are conflicting data regarding the role of the National Early Warning Score 2 (NEWS2) in predicting adverse outcomes in patients with infectious diseases. New-onset atrial fibrillation (NO-AF) has been suggested as a sepsis-defining… read more here.
Keywords: suspected bacterial; bacterial infections; composite endpoint; early warning ... See more keywords