Consistency-ensured parametric tests for critical events of composite endpoints
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DOI: 10.1080/10543406.2017.1397678
Abstract: ABSTRACT Composite endpoints (CEs) are commonly used in clinical trials when clinically important events are rare or when the disease is multifaceted. However, components of a CE often differ markedly in their clinical importance. The… read more here.
Keywords: consistency ensured; clinically important; composite endpoints; important components ... See more keywords
Interpretation of composite endpoints in urology: an analysis of citation quality
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DOI: 10.1080/21681805.2022.2058607
Abstract: Abstract Objective To investigate how urological studies using composite endpoints as the primary outcome were cited. Materials and methods In this quality analysis of citations, three randomized clinical trials each investigating oncological and non-oncological urology… read more here.
Keywords: quality; composite endpoints; citation; urology ... See more keywords
Adaptive clinical trial designs with blinded selection of binary composite endpoints and sample size reassessment.
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DOI: 10.1093/biostatistics/kxac040
Abstract: For randomized clinical trials where a single, primary, binary endpoint would require unfeasibly large sample sizes, composite endpoints (CEs) are widely chosen as the primary endpoint. Despite being commonly used, CEs entail challenges in designing… read more here.
Keywords: sample size; primary endpoint; endpoint; trial ... See more keywords
Shifting Clinical Trial Endpoints in Kidney Transplantation: The Rise of Composite Endpoints and Machine Learning to Refine Prognostication
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DOI: 10.1097/tp.0000000000004107
Abstract: The measurement of outcomes in kidney transplantation has been more accurately documented than almost any other surgical procedure result in recent decades. With significant improvements in short- and long-term outcomes related to optimized immunosuppression, outcomes… read more here.
Keywords: learning refine; machine learning; composite endpoints; transplantation ... See more keywords
On the analysis of composite measures of quality in medical research
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DOI: 10.1177/0962280214553330
Abstract: Composite endpoints are commonplace in biomedical research. The complex nature of many health conditions and medical interventions demand that composite endpoints be employed. Different approaches exist for the analysis of composite endpoints. A Monte Carlo… read more here.
Keywords: research; regression; regression model; effect ... See more keywords
The maraca plot: A novel visualization of hierarchical composite endpoints
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DOI: 10.1177/17407745221134949
Abstract: Background: Hierarchical composite endpoints are complex endpoints combining outcomes of different types and different clinical importance into an ordinal outcome that prioritizes the clinically most important (e.g. most severe) event of a patient. Hierarchical composite… read more here.
Keywords: visualization; endpoint; hierarchical composite; composite endpoints ... See more keywords