Design, synthesis, and biological evaluation of a novel series of 2-(2,6-dioxopiperidin-3-yl)isoquinoline-1,3(2H,4H)-dione derivatives as cereblon modulators
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DOI: 10.1080/14756366.2022.2087219
Abstract: Abstract In the current study, we designed and synthesised a novel series of 2-(2,6-dioxopiperidin-3-yl)isoquinoline-1,3(2H,4H)-dione derivatives as cereblon (CRBN) modulators. The results of the CCK8 assay revealed potent antiproliferative activity for the selected compound 10a against… read more here.
Keywords: novel series; isoquinoline dione; series dioxopiperidin; compound 10a ... See more keywords
Discovery of novel conjugates of quinoline and thiazolidinone urea as potential anti-colorectal cancer agent
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DOI: 10.1080/14756366.2022.2117318
Abstract: Abstract Based on the obtained SARs, further structural optimisation of compound BC2021-104511-15i was conducted in this investigation, and totally ten novel quinoline derivates were designed, synthesised and optimised for biological activity. Among them, compound 10a… read more here.
Keywords: conjugates quinoline; discovery novel; colo 205; 205 cells ... See more keywords