New acrylamide-substituted quinazoline derivatives with enhanced potency for the treatment of EGFR T790M-mutant non-small-cell lung cancers.
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DOI: 10.1016/j.bioorg.2018.01.035
Abstract: A new class of acrylamide-substituted quinazoline derivatives with enhanced inhibitory activity against mutant EGFR T790M enzyme were synthesized. Among them, compound 10b displayed the strongest inhibitory potency to block the phosphorylation of the EGFR T790M… read more here.
Keywords: egfr; compound 10b; egfr t790m; t790m ... See more keywords