Interaction between bioactive compound 11a-N-tosyl-5-deoxi-pterocarpan (LQB-223) and Calf thymus DNA: Spectroscopic approach, electrophoresis and theoretical studies.
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DOI: 10.1016/j.ijbiomac.2016.12.044
Abstract: The interaction of small molecules with DNA has been quite important, since this biomolecule is currently the major target for a wide range of drugs in clinical use or advanced clinical research phase. Thus, the… read more here.
Keywords: pterocarpan lqb; bioactive compound; dna; lqb 223 ... See more keywords
Novel C-3 and C-20 derived analogs of betulinic acid as potent cytotoxic agents: design, synthesis, in vitro and in silico studies
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DOI: 10.1039/d5ra01038a
Abstract: In this report, novel derivatives of betulinic acid were designed and synthesized by targeting the C-3-OH group and C-20 olefinic bond in an endeavour to develop potent antitumor agents. These analogs were screened for their… read more here.
Keywords: cancer; compound 11a; betulinic acid; novel derived ... See more keywords