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Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2112575
Abstract: Abstract New 1H-pyrazolo[3,4-d]pyrimidine derivatives were designed and synthesised to act as epidermal growth factor receptor inhibitors (EGFRIs). The synthesised derivatives were assessed for their in vitro anti-proliferative activities against A549 and HCT-116 cancer cells. Compounds…
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Keywords:
new pyrazolo;
egfrwt egfrt790m;
pyrazolo pyrimidine;
compound 12b ... See more keywords
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Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15020246
Abstract: Over the past few decades, the development of broad-spectrum anticancer agents with anti-angiogenic activity has witnessed considerable progress. In this study, a new series of pyrazolo[3,4-d]pyrimidines based on a phenylfuroxan scaffold were designed, synthesized, and…
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Keywords:
compound;
mapk signaling;
inhibitor;
compound 12b ... See more keywords