Discovery of 2,4-diarylaminopyrimidines bearing a resorcinol motif as novel ALK inhibitors to overcome the G1202R resistant mutation.
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DOI: 10.1016/j.ejmech.2017.12.060
Abstract: To address drug resistance caused by ALK kinase mutations, especially the most refractory and predominant mutation G1202R for the second-generation ALK inhibitor, a series of new diarylaminopyrimidine analogues were designed by incorporating a resorcinol moiety… read more here.
Keywords: alk; g1202r; generation; resorcinol ... See more keywords