Design, synthesis and biological evaluation of indole-2-one derivatives as potent BRD4 inhibitors.
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DOI: 10.1016/j.ejmech.2020.112780
Abstract: Bromodomain protein 4 (BRD4) plays a crucial role in transcriptional regulation and is considered to be a viable drug target for cancer treatment. Herein, we designed and synthesized a series of indole-2-one derivatives through scaffold… read more here.
Keywords: design synthesis; compound 12j; one derivatives; indole one ... See more keywords