Discovery of novel vinyl sulfone derivatives as anti-tumor agents with microtubule polymerization inhibitory and vascular disrupting activities.
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DOI: 10.1016/j.ejmech.2018.08.074
Abstract: Vinyl sulfone or sulfoxide moieties were firstly introduced to the structure of chalcone compound by replacing the carbonyl group to afford a series of novel compounds as potential anti-tubulin agents. All of the target compounds… read more here.
Keywords: cell; vinyl sulfone; compound 12m; tumor ... See more keywords