Discovery of a novel 2,4‐thiazolidinedione derivative as dual inhibitor of β‐catenin/TCF4 interaction and tubulin polymerization in colon cancer cells
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DOI: 10.1002/ardp.202400796
Abstract: Hyperactivation of the Wnt/β‐catenin signaling pathway has been widely recognized as a pathogenic mechanism for colorectal cancer (CRC). Based on a previously reported lead compound, iCRT14, a series of 2,4‐thiazolidinedione derivatives were designed, synthesized, and… read more here.
Keywords: cancer; cancer cells; catenin; catenin tcf4 ... See more keywords