In Vitro Pharmacological Profile of a New Small Molecule Bradykinin B2 Receptor Antagonist
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.00916
Abstract: We here report the discovery and early characterization of Compound 3, a representative of a novel class of small molecule bradykinin (BK) B2 receptor antagonists, and its superior profile to the prior art B2 receptor… read more here.
Keywords: bradykinin receptor; compound compound; compound; receptor ... See more keywords
Preparative Separation of Phenylethanoid and Secoiridoid Glycosides from Ligustri Lucidi Fructus by High-Speed Counter-Current Chromatography Coupled with Ultrahigh Pressure Extraction
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DOI: 10.3390/molecules23123353
Abstract: Three phenylethanoid glycosides, echinacoside (1), salidroside (3), and acteoside (6), and three secoiridoid glycosides, isonuezhenide (2), nuezhenoside G13 (4), and specnuezhenide (5), have been extracted and separated by a combined method of ultrahigh pressure extraction… read more here.
Keywords: extraction; compound compound; separation; secoiridoid glycosides ... See more keywords
Virtual Screening Based on Machine Learning Explores Mangrove Natural Products as KRASG12C Inhibitors
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DOI: 10.3390/ph15050584
Abstract: Mangrove secondary metabolites have many unique biological activities. We identified lead compounds among them that might target KRASG12C. KRAS is considered to be closely related to various cancers. A variety of novel small molecules that… read more here.
Keywords: compound; natural products; compound compound; virtual screening ... See more keywords
Static Permittivity and Electro-Optical Properties of Bi-Component Orthoconic Antiferroelectric Liquid Crystalline Mixtures Targeted for Polymer Stabilized Sensing Systems
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DOI: 10.3390/polym14050956
Abstract: The behavior of two newly formulated bi-component orthoconic antiferroelectric liquid crystalline (OAFLC) systems, i.e., the Compound A + Compound B mixture system and Compound C + Compound B mixture system has been discussed in light… read more here.
Keywords: compound; compound compound; antiferroelectric liquid; orthoconic antiferroelectric ... See more keywords