A class of novel tubulin polymerization inhibitors exert effective anti-tumor activity via mitotic catastrophe.
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DOI: 10.1016/j.ejmech.2018.12.030
Abstract: In current work, a class of novel 4,5-dihydro-1H-pyrazole-1-carboxylate derivatives (E01-E28) were designed, synthesized and evaluated. Among them, the most potent compound E24 exhibited comparable activity against a panel of cancer cells (GI50 ranging 0.05-0.98 μM) and… read more here.
Keywords: class novel; tubulin polymerization; tubulin; compound e24 ... See more keywords